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Mouse Anti-GPR3 Recombinant Antibody (CBLG1-1640) (CBMAB-G4654-LY)

This product is antibody recognizes GPR3. The antibody CBLG1-1640 immunoassay techniques such as: ELISA, WB.
See all GPR3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-1640
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G protein-coupled receptor 3
Introduction
This gene is a member of the G protein-coupled receptor family and is found in the cell membrane. G protein-coupled receptors, characterized by a seven transmembrane domain motif, are involved in translating outside signals into G protein mediated intracellular effects. The encoded protein activates adenylate cyclase and modulates amyloid-beta production in a mouse model, suggesting that it may play a role in Alzheimer's disease. [provided by RefSeq, Oct 2012]
Entrez Gene ID
2827
UniProt ID
P46089
Alternative Names
G Protein-Coupled Receptor 3; ACCA Orphan Receptor; ACCA; Adenylate Cyclase Constitutive Activator; G-Protein Coupled Receptor 3;
Function
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity).

Maintains also meiotic arrest in oocytes (By similarity).
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Regulation of meiotic nuclear division Source: Ensembl
Regulation of metabolic process Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-42
Helical: 43-62
Cytoplasmic: 63-74
Helical: 75-98
Extracellular: 99-110
Helical: 111-132
Cytoplasmic: 133-153
Helical: 154-173
Extracellular: 174-198
Helical: 199-217
Cytoplasmic: 218-245
Helical: 246-272
Extracellular: 273-277
Helical: 278-299
Cytoplasmic: 300-330

Bharathi, & Roy, K. K. (2022). Structural basis for the binding of a selective inverse agonist AF64394 with the human G-protein coupled receptor 3 (GPR3). Journal of Biomolecular Structure and Dynamics, 40(20), 10181-10190.

Iorio, C., Rourke, J. L., Wells, L., Sakamaki, J. I., Moon, E., Hu, Q., ... & Screaton, R. A. (2021). Silencing the G-protein coupled receptor 3-salt inducible kinase 2 pathway promotes human β cell proliferation. Communications Biology, 4(1), 907.

Wu, J., Chen, N., Liu, Y., Godlewski, G., Kaplan, H. J., Shrader, S. H., ... & Shao, H. (2021). Studies of involvement of G-protein coupled receptor-3 in cannabidiol effects on inflammatory responses of mouse primary astrocytes and microglia. PLoS One, 16(5), e0251677.

Iorio, C., Rourke, J. L., Wells, L., Sakamaki, J. I., Moon, E., Hu, Q., ... & Screaton, R. A. (2021). Role of the G-Protein Coupled Receptor 3-Salt Inducible Kinase 2 Pathway in Human β Cell Proliferation. bioRxiv, 2021-05.

Watkins, L. R., & Orlandi, C. (2020). Orphan G protein coupled receptors in affective disorders. Genes, 11(6), 694.

Azam, S., Haque, M. E., Jakaria, M., Jo, S. H., Kim, I. S., & Choi, D. K. (2020). G-protein-coupled receptors in CNS: a potential therapeutic target for intervention in neurodegenerative disorders and associated cognitive deficits. Cells, 9(2), 506.

Laun, A. S., Shrader, S. H., Brown, K. J., & Song, Z. H. (2019). GPR3, GPR6, and GPR12 as novel molecular targets: their biological functions and interaction with cannabidiol. Acta Pharmacologica Sinica, 40(3), 300-308.

Capaldi, S., Suku, E., Antolini, M., Di Giacobbe, M., Giorgetti, A., & Buffelli, M. (2018). Allosteric sodium binding cavity in GPR3: a novel player in modulation of Aβ production. Scientific reports, 8(1), 11102.

Firmani, L. (2018). The G Protein-Coupled Receptor, GPR3, Promotes the Acquisition of Oocyte Meiotic Competence.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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