Rabbit Anti-GPR63 Recombinant Antibody (EG1406) (CBMAB-EN1685-LY)

The product is antibody recognizes GPR63. The antibody EG1406 immunoassay techniques such as: IF: 1:100~1:500 ELISA: 1:20000.
See all GPR63 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse

Clone

EG1406

Antibody Isotype

IgG

Application

IF: 1:100~1:500 ELISA: 1:20000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from internal of human GPR63.

Specificity

Human, Mouse

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

G protein-coupled receptor 63

Introduction

This gene encodes a G protein-coupled receptor. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Entrez Gene ID

Human	81491
Mouse	81006

UniProt ID

Human	Q9BZJ6
Mouse	Q9EQQ3

Alternative Names

PSP24B; PSP24(beta)

Function

Orphan receptor. May play a role in brain function.

Biological Process

G protein-coupled receptor signaling pathway Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-81
Helical: 82-104
Cytoplasmic: 105-115
Helical: 116-138
Extracellular: 139-157
Helical: 158-177
Cytoplasmic: 178-196
Helical: 197-216
Extracellular: 217-240
Helical: 241-263
Cytoplasmic: 264-315
Helical: 316-338
Extracellular: 339-352
Helical: 353-375
Cytoplasmic: 376-419

References

Zeng, S., Liang, Y., Hu, H., Wang, F., & Liang, L. (2022). Endothelial cell-derived S1P promotes migration and stemness by binding with GPR63 in colorectal cancer. Pathology-Research and Practice, 240, 154197.

Nagarajan, S., Qian, Z. Y., Marimuthu, P., Alkayed, N. J., Kaul, S., & Barnes, A. P. (2021). Mapping the molecular architecture required for lipid-binding pockets using a subset of established and orphan G-protein coupled receptors. Journal of chemical information and modeling, 61(7), 3442-3452.

Snedeker, J., Gibbons Jr, W. J., Paulding, D. F., Abdelhamed, Z., Prows, D. R., & Stottmann, R. W. (2019). Gpr63 is a modifier of microcephaly in Ttc21b mouse mutants. PLoS Genetics, 15(11), e1008467.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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Documents

Datasheet
SDS
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Second antibody and isotype control

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