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Rabbit Anti-GRIA2/GRIA3 Recombinant Antibody (CBNH-058) (CBMAB-R4383-CN)

This product is a rabbit recombinant antibody that recognizes GRIA2/GRIA3. The antibody CBNH-058 can be used for immunoassay techniques such as: ELISA, IF.
See all GRIA2/GRIA3 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBNH-058
Antibody Isotype
IgG
Application
ELISA, IF

Basic Information

Immunogen
A synthesized peptide derived from human GRIA2/GRIA3
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 150 mM Sodium chloride, 50% Glycerol
Preservative
0.02% Sodium azide
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target

Full Name
Glutamate ionotropic receptor AMPA type subunit 2
Introduction
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing (CAG->CGG; Q->R) within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, (including the flip and flop isoforms that vary in their signal transduction properties), has been noted for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
2309
UniProt ID
O43524
Alternative Names
GLUR2; GLURB; GluA2; HBGR2; GluR-K2
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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