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Mouse Anti-GRM7 (AA 431-520) Recombinant Antibody (CBFYH-0496) (CBMAB-H1365-FY)

This product is mouse antibody that recognizes GRM7. The antibody CBFYH-0496 can be used for immunoassay techniques such as: ELISA, WB.
See all GRM7 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-0496
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
GRM7 AA 431-520 partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 431-520

Target

Full Name
glutamate metabotropic receptor 7
Introduction
L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
UniProt ID
Alternative Names
Glutamate Metabotropic Receptor 7; Protein Phosphatase 1, Regulatory Subunit 87; Glutamate Receptor, Metabotropic 7; GPRC1G; MGLUR7; Metabotropic Glutamate Receptor 7; PPP1R87; GLUR7; MGLU7
Function
G-protein coupled receptor activated by glutamate that regulates axon outgrowth through the MAPK-cAMP-PKA signaling pathway during neuronal development (PubMed:33500274).

Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase that it inhibits (PubMed:9473604).
Biological Process
Adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway Source: UniProtKB
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Axon development Source: UniProtKB
Chemical synaptic transmission Source: UniProtKB
Glycosylation Source: UniProtKB
G protein-coupled glutamate receptor signaling pathway Source: GO_Central
Negative regulation of glutamate secretion Source: UniProtKB
Regulation of synaptic transmission, glutamatergic Source: GO_Central
Sensory perception of sound Source: UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Neurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities (NEDSHBA):
An autosomal recessive neurodevelopmental disorder characterized by global developmental delay, hypotonia, severe to profound intellectual disability, early-onset epilepsy, and microcephaly. Neuroimaging shows cerebral atrophy, thin corpus callosum and hypomyelination in a majority of cases. Death in childhood may occur.
Topology
Extracellular: 35-590
Helical: 591-615
Cytoplasmic: 616-627
Helical: 628-648
Extracellular: 649-654
Helical: 655-675
Cytoplasmic: 676-702
Helical: 703-723
Extracellular: 724-753
Helical: 754-775
Cytoplasmic: 776-788
Helical: 789-810
Extracellular: 811-825
Helical: 826-850
Cytoplasmic: 851-915
PTM
N-glycosylated.

Chaumette, B., Sengupta, S. M., Lepage, M., Malla, A., Iyer, S. N., Kebir, O., ... & ICAAR study group. (2022). A polymorphism in the glutamate metabotropic receptor 7 is associated with cognitive deficits in the early phases of psychosis. Schizophrenia Research, 249, 56-62.

Jdila, M. B., Mignon-Ravix, C., Ncir, S. B., Kammoun, F., Fakhfakh, F., Villard, L., & Triki, C. (2021). A large consanguineous family with a homozygous Metabotropic Glutamate Receptor 7 (mGlu7) variant and developmental epileptic encephalopathy: Effect on protein structure and ligand affinity. Orphanet journal of rare diseases, 16(1), 1-12.

Fisher, N. M., AlHashim, A., Buch, A. B., Badivuku, H., Samman, M. M., Weiss, K. M., ... & Niswender, C. M. (2021). A GRM7 mutation associated with developmental delay reduces mGlu7 expression and produces neurological phenotypes. JCI insight, 6(4).

Safari, M. R., Beirami, A. D., Khazaie, M., Komaki, A., Noroozi, R., Ghafouri-Fard, S., & Taheri, M. (2020). GRM7 polymorphisms are not associated with ischemic stroke in Iranian population. Nucleosides, Nucleotides & Nucleic Acids, 39(5), 792-798.

Liang, W., Yu, H., Su, Y., Lu, T., Yan, H., Yue, W., & Zhang, D. (2020). Variants of GRM7 as risk factor and response to antipsychotic therapy in schizophrenia. Translational Psychiatry, 10(1), 83.

Noroozi, R., Taheri, M., Omrani, M. D., & Ghafouri-Fard, S. (2019). Glutamate receptor metabotropic 7 (GRM7) gene polymorphisms in mood disorders and attention deficit hyperactive disorder. Neurochemistry International, 129, 104483.

Mazdeh, M., Noroozi, R., Komaki, A., Azari, I., Ghafouri-Fard, S., & Taheri, M. (2019). A single nucleotide polymorphism in the metabotropic glutamate receptor 7 gene is associated with multiple sclerosis in Iranian population. Multiple sclerosis and related disorders, 28, 189-192.

Sun, Q., Yuan, F., Yuan, R., Ren, D., Zhu, Y., Bi, Y., ... & He, G. (2019). GRIK4 and GRM7 gene may be potential indicator of venlafaxine treatment reponses in Chinese of Han ethnicity. Medicine, 98(19).

Fisher, N. M., Seto, M., Lindsley, C. W., & Niswender, C. M. (2018). Metabotropic glutamate receptor 7: a new therapeutic target in neurodevelopmental disorders. Frontiers in molecular neuroscience, 11, 387.

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For research use only. Not intended for any clinical use.

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