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Mouse Anti-GRP Recombinant Antibody (3A11) (CBMAB-G5094-LY)

This product is antibody recognizes GRP. The antibody 3A11 immunoassay techniques such as: ELISA, WB.
See all GRP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3A11
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
gastrin-releasing peptide
Introduction
This gene encodes a member of the bombesin-like family of gastrin-releasing peptides. The encoded preproprotein is proteolytically processed to generate two peptides, gastrin-releasing peptide and neuromedin-C. These peptides regulate numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation. These peptides are also likely to play a role in human cancers of the lung, colon, stomach, pancreas, breast, and prostate. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. [provided by RefSeq, Jan 2016]
Entrez Gene ID
2922
UniProt ID
P07492
Alternative Names
Gastrin Releasing Peptide; Gastrin-Releasing Peptide; Neuromedin C; Prepro-GRP; Bombesin; Pre-Progastrin Releasing Peptide;
Function
Stimulates the release of gastrin and other gastrointestinal hormones (By similarity).

Contributes to the perception of prurient stimuli and to the transmission of itch signals in the spinal cord that promote scratching behavior. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory. Contributes to the regulation of food intake (By similarity).
Biological Process
Neuropeptide signaling pathway Source: MGI
Positive regulation of peptide hormone secretion Source: UniProtKB
Positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Psychomotor behavior Source: Ensembl
Response to external biotic stimulus Source: Ensembl
Signal transduction Source: ProtInc
Social behavior Source: Ensembl
Cellular Location
Secreted; Secretory vesicle lumen

Gutierrez-Mecinas, M., Kókai, É., Polgár, E., Quillet, R., Titterton, H. F., Weir, G. A., ... & Todd, A. J. (2023). Antibodies Against the Gastrin-releasing Peptide Precursor Pro-Gastrin-releasing Peptide Reveal Its Expression in the Mouse Spinal Dorsal Horn. Neuroscience, 510, 60-71.

Gomena, J., Vári, B., Oláh-Szabó, R., Biri-Kovács, B., Bősze, S., Borbély, A., ... & Mező, G. (2023). Targeting the Gastrin-Releasing Peptide Receptor (GRP-R) in Cancer Therapy: Development of Bombesin-Based Peptide–Drug Conjugates. International Journal of Molecular Sciences, 24(4), 3400.

Hirooka, A., Hamada, M., Fujiyama, D., Takanami, K., Kobayashi, Y., Oti, T., ... & Sakamoto, H. (2021). The gastrin-releasing peptide/bombesin system revisited by a reverse-evolutionary study considering Xenopus. Scientific reports, 11(1), 1-15.

Kayalar, O., Oztay, F., & Ongen, H. G. (2020). Gastrin-releasing peptide induces fibrotic response in MRC5s and proliferation in A549s. Cell Communication and Signaling, 18, 1-12.

Barry, D. M., Liu, X. T., Liu, B., Liu, X. Y., Gao, F., Zeng, X., ... & Chen, Z. F. (2020). Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors. Nature communications, 11(1), 1397.

Choi, Y., Heo, S. C., Kim, Y. N., Joo, J. Y., Hwang, J. J., Bae, M. K., & Kim, H. J. (2020). Gastrin-releasing peptide (GRP) stimulates osteoclastogenesis in periodontitis. Cells, 10(1), 50.

Pagani, M., Albisetti, G. W., Sivakumar, N., Wildner, H., Santello, M., Johannssen, H. C., & Zeilhofer, H. U. (2019). How gastrin-releasing peptide opens the spinal gate for itch. Neuron, 103(1), 102-117.

Morgat, C., Schollhammer, R., Macgrogan, G., Barthe, N., Vélasco, V., Vimont, D., ... & Hindié, E. (2019). Comparison of the binding of the gastrin-releasing peptide receptor (GRP-R) antagonist 68Ga-RM2 and 18F-FDG in breast cancer samples. PloS one, 14(1), e0210905.

Dickie, A. C., Bell, A. M., Iwagaki, N., Polgár, E., Gutierrez-Mecinas, M., Kelly, R., ... & Todd, A. J. (2019). Morphological and functional properties distinguish the substance P and gastrin-releasing peptide subsets of excitatory interneuron in the spinal cord dorsal horn. Pain, 160(2), 442.

Gnesin, S., Cicone, F., Mitsakis, P., Van der Gucht, A., Baechler, S., Miralbell, R., ... & Prior, J. O. (2018). First in-human radiation dosimetry of the gastrin-releasing peptide (GRP) receptor antagonist 68Ga-NODAGA-MJ9. EJNMMI research, 8(1), 1-10.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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