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Recombinant Mouse Anti-HLA DQ3 Recombinant Antibody (2HB6) (CBMAB-XB0540-YC)

Provided herein is a Mouse Recombinant Antibody against HLA DQ3. The antibody can be used for immunoassay techniques, such as ELISA, FC, IHC, IP, RIA, WB.
See all HLA DQ3 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human
Clone
2HB6
Antibody Isotype
IgG1
Application
ELISA, FC, IHC, IP, RIA, WB

Basic Information

Immunogen
ATL mouse spleen cells and PRIESS (HLA-DR4) cells.
Specificity
Mouse, Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
HLA DQ3
Introduction
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T-cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in mhc ii-a/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, DQ, DP and DR) by sustaining a conformation that favors peptide exchange. RFLP analysis of HLA-DM genes from rheumatoid arthritis (RA) patients suggests that certain polymorphisms are genetic factors for RA susceptibility. The alpha 1 chain of HLA-DQ1 class II molecule (Ia antigen) complex can bind peptides and present them to CD4+ T lymphocytes.
Alternative Names
HLA-DQ3
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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