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Recombinant Mouse Anti-HLA DRB Recombinant Antibody (31.1) (CBMAB-XB0555-YC)

Provided herein is a Mouse Recombinant Antibody against Leukocyte Antigen DR, Beta Chain. The antibody can be used for immunoassay techniques, such as ELISA, FC, RIA.
See all HLA DRB antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
31.1
Antibody Isotype
IgG1
Application
ELISA, FC, RIA

Basic Information

Immunogen
Ia fraction from Jy human B lymphoblastoid cell line. Class II from JY human B lymphoblastoid cell line.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Leukocyte Antigen DR, Beta Chain
Introduction
Major histocompatibility complex (MHC) class II molecules destined for presentation to CD4+ helper T-cells is determined by two key events. These events include the dissociation of class II-associated invariant chain peptides (CLIP) from an antigen binding groove in mhc ii-a/b dimers through the activity of MHC molecules HLA-DM and -DO, and subsequent peptide antigen binding. Accumulating in endosomal/lysosomal compartments and on the surface of B cells, HLA-DM, -DO molecules regulate the dissociation of CLIP and the subsequent binding of exogenous peptides to HLA class II molecules (HLA-DR, DQ, DP and DR) by sustaining a conformation that favors peptide exchange.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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