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Rabbit Anti-HRH2 Recombinant Antibody (EG1554) (CBMAB-EN1855-LY)

The product is antibody recognizes HRH2. The antibody EG1554 immunoassay techniques such as: IF: 1:100~1:500 ELISA: 1:1000.
See all HRH2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1554
Antibody Isotype
IgG
Application
IF: 1:100~1:500 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human HRH2.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Histamine Receptor H2
Introduction
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. Histamine receptor H2 belongs to the family 1 of G protein-coupled receptors. It is an integral membrane protein and stimulates gastric acid secretion. It also regulates gastrointestinal motility and intestinal secretion and is thought to be involved in regulating cell growth and differentiation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Entrez Gene ID
3274
UniProt ID
P25021
Alternative Names
Histamine Receptor H2; Gastric Receptor I; HH2R; H2R; Histamine H2 Receptor; Gastric Receptor 1;
Function
The H2 subclass of histamine receptors mediates gastric acid secretion. Also appears to regulate gastrointestinal motility and intestinal secretion. Possible role in regulating cell growth and differentiation. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and, through a separate G protein-dependent mechanism, the phosphoinositide/protein kinase (PKC) signaling pathway (By similarity).
Biological Process
Chemical synaptic transmission Source: GO_Central
Gastric acid secretion Source: InterPro
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Immune response Source: ProtInc
Positive regulation of vasoconstriction Source: InterPro
Cellular Location
Cell membrane
Topology
Extracellular: 1-22
Helical: 23-44
Cytoplasmic: 45-57
Helical: 58-81
Extracellular: 82-92
Helical: 93-114
Cytoplasmic: 115-134
Helical: 135-159
Extracellular: 160-180
Helical: 181-204
Cytoplasmic: 205-234
Helical: 235-258
Extracellular: 259-267
Helical: 268-289
Cytoplasmic: 290-359

Ma, Q., Jiang, L., Chen, H., An, D., Ping, Y., Wang, Y., ... & Hu, W. (2023). Histamine H2 receptor deficit in glutamatergic neurons contributes to the pathogenesis of schizophrenia. Proceedings of the National Academy of Sciences, 120(9), e2207003120.

Patel, A., Marquez-Gomez, P. L., Torp, L. R., Gao, L., & Peralta-Yahya, P. (2023). Insight into the Mode of Action of 8-Hydroxyquinoline-Based Blockers on the Histamine Receptor 2. Biosensors, 13(6), 571.

Marquez-Gomez, P. L., Kruyer, N. S., Eisen, S. L., Torp, L. R., Howie, R. L., Jones, E. V., ... & Peralta-Yahya, P. (2022). Discovery of 8-hydroxyquinoline as a histamine receptor 2 blocker scaffold. ACS Synthetic Biology, 11(8), 2820-2828.

Fultz, R., Engevik, M. A., Shi, Z., Hall, A., Herrmann, B., Ganesh, B. P., ... & Versalovic, J. (2019). Phagocytosis by macrophages depends on histamine H2 receptor signaling and scavenger receptor 1. Microbiologyopen, 8(10), e908.

Shi, Z., Fultz, R. S., Engevik, M. A., Gao, C., Hall, A., Major, A., ... & Versalovic, J. (2019). Distinct roles of histamine H1-and H2-receptor signaling pathways in inflammation-associated colonic tumorigenesis. American Journal of Physiology-Gastrointestinal and Liver Physiology, 316(1), G205-G216.

Leary, P. J., Kronmal, R. A., Bluemke, D. A., Buttrick, P. M., Jones, K. L., Kao, D. P., ... & Bristow, M. R. (2018). Histamine H2 receptor polymorphisms, myocardial transcripts, and heart failure (from the multi-ethnic study of atherosclerosis and beta-blocker effect on remodeling and gene expression trial). The American journal of cardiology, 121(2), 256-261.

Singh, V., Gohil, N., & Ramírez‐García, R. (2018). New insight into the control of peptic ulcer by targeting the histamine H2 receptor. Journal of Cellular Biochemistry, 119(2), 2003-2011.

Moisejevs, G., Gailîte, L., Isajevs, S., Nikitina-Zaķe, L., Kempa, I., Jančiauskas, D., ... & Leja, M. (2018, December). Lack of Association Between Rs2067474 Polymorphism in the Histamine Receptor H2 Gene and Gastric Cancer In Latvian Population. In Proceedings of the Latvian Academy of Sciences, Section B: Natural, Exact, and Applied Sciences.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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