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Mouse Anti-HSPB3 (AA 1-205) Recombinant Antibody (CBFYH-2372) (CBMAB-H3386-FY)

This product is mouse antibody that recognizes HSPB3. The antibody CBFYH-2372 can be used for immunoassay techniques such as: ELISA, WB.
See all HSPB3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYH-2372
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Anti-human HSP27 mAb, is derived from hybridization of mouse SP2/0 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human HSP27 amino acids 1-205 purified from E.coli
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-205

Target

Full Name
Heat Shock Protein Family B (Small) Member 3
Introduction
This gene encodes a muscle-specific small heat shock protein. A mutation in this gene is the cause of autosomal dominant distal hereditary motor neuropathy type 2C.
Entrez Gene ID
8988
UniProt ID
Q12988
Alternative Names
Heat Shock Protein Family B (Small) Member 3; Heat Shock 27kDa Protein 3; Heat Shock 17 KDa Protein; Protein 3; HSP 17; HSPL27; Heat Shock 27kD Protein 3
Function
Inhibitor of actin polymerization.
Biological Process
Response to unfolded protein Source: ProtInc
Cellular Location
Nucleus; Cytoplasm. Translocates to nuclear foci during heat shock.
Involvement in disease
Neuronopathy, distal hereditary motor, 2C (HMN2C):
A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs.

Gianniou, D. D., Sklirou, A. D., Papadimitriou, M. A., Pilala, K. M., Stravodimos, K., Avgeris, M., ... & Trougakos, I. P. (2023). Evaluation of the Small Heat Shock Protein Family Members HSPB2 and HSPB3 in Bladder Cancer Prognosis and Progression. International Journal of Molecular Sciences, 24(3), 2609.

Benndorf, R., Velazquez, R., Zehr, J. D., Pond, S. L. K., Martin, J. L., & Lucaci, A. G. (2022). Human HspB1, HspB3, HspB5 and HspB8: Shaping these disease factors during vertebrate evolution. Cell Stress and Chaperones, 27(4), 309-323.

Tiago, T., Hummel, B., Morelli, F. F., Basile, V., Vinet, J., Galli, V., ... & Carra, S. (2021). Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor. Cell death & disease, 12(5), 452.

PINHEIRO TIAGO, T. S. (2021). Studio delle funzioni fisiologiche e delle implicazioni patologiche di HSPB3, il membro più deviante della famiglia delle HSPB.

BARALDI, L. (2021). Caratterizzazione dell'espressione e della distribuzione subcellulare di HSPB3, proteina espressa nelle cellule muscolari scheletriche, le cui mutazioni sono state associate a miopatia e neuropatia motoria.

Kalioraki, M. A., Artemaki, P. I., Sklirou, A. D., Kontos, C. K., Adamopoulos, P. G., Papadopoulos, I. N., ... & Scorilas, A. (2020). Heat shock protein beta 3 (HSPB3) is an unfavorable molecular biomarker in colorectal adenocarcinoma. Molecular carcinogenesis, 59(1), 116-125.

Nam, D. E., Nam, S. H., Lee, A. J., Hong, Y. B., Choi, B. O., & Chung, K. W. (2018). Small heat shock protein B3 (HSPB3) mutation in an axonal Charcot‐Marie‐Tooth disease family. Journal of the Peripheral Nervous System, 23(1), 60-66.

Clark, A. R., Egberts, W. V., Kondrat, F. D., Hilton, G. R., Ray, N. J., Cole, A. R., ... & Slingsby, C. (2018). Terminal regions confer plasticity to the tetrameric assembly of human HspB2 and HspB3. Journal of molecular biology, 430(18), 3297-3310.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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