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Mouse Anti-IAV H7N7 HA Recombinant Antibody (CBMW-H1071) (CBMAB-V208-1221-FY)

This product is mouse antibody that recognizes IAV H7N7 HA. The antibody CBMW-H1071 can be used for immunoassay techniques such as: ELISA, IF, IP.
See all IAV H7N7 HA antibodies

Summary

Host Animal
Mouse
Specificity
IAV
Clone
CBMW-H1071
Antibody Isotype
IgG1
Application
ELISA, IF, IP

Basic Information

Immunogen
DNA vaccine expressing HA (H7N7/England/268/96)
Specificity
IAV
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Influenza A Virus Hemagglutinin
Introduction
Influenza A virus causes influenza in birds and some mammals, and is the only species of the Alphainfluenzavirus genus of the Orthomyxoviridae family of viruses.
Alternative Names
IAV H7N7 HA H 7; Influenza A Virus H7N7 HA H 7
Function
Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization either through clathrin-dependent endocytosis or through clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.

Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore.
Biological Process
Clathrin-dependent endocytosis of virus by host cell Source: UniProtKB-UniRule
Fusion of virus membrane with host endosome membrane Source: UniProtKB-UniRule
Fusion of virus membrane with host plasma membrane Source: InterPro
Viral budding from plasma membrane Source: UniProtKB-UniRule
Virion attachment to host cell Source: UniProtKB-KW
Cellular Location
Virion membrane; Host apical cell membrane. Abundantly expressed at the apical plasma membrane in infected polarized epithelial cells, in close proximity to budding and assembled virions. Minor component of virions (only 16-20 molecules/virion).
Topology
Extracellular: 19-529
Helical: 530-550
Cytoplasmic: 551-563
PTM
Palmitoylated.
In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoprotease secreted by the bronchial epithelial cells. One identified protease that may be involved in this process is secreted in lungs by Clara cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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