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Rabbit Anti-INPP4A Recombinant Antibody (EP3425(2)) (CBMAB-I1258-YY)

This product is Rabbit antibody that recognizes INPP4A. The antibody EP3425(2) can be used for immunoassay techniques such as: WB, IHC-P, ICC
See all INPP4A antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
EP3425(2)
Antibody Isotype
IgG
Application
WB, IHC-P, ICC

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Inositol Polyphosphate-4-Phosphatase Type I A
Introduction
This gene encodes an Mg++ independent enzyme that hydrolyzes the 4-position phosphate from the inositol ring of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate, and inositol 3,4-bisphosphate. Multiple transcript variants encoding distinct isoforms have been described.
Entrez Gene ID
Human3631
Mouse269180
Rat80849
UniProt ID
HumanQ96PE3
MouseQ9EPW0
RatQ62784
Alternative Names
Inositol Polyphosphate-4-Phosphatase Type I A
Function
Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) (PubMed:20463662, PubMed:15716355).
Catalyzes also inositol 1,3,4-trisphosphate and inositol 1,4-bisphosphate (By similarity).
Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival (PubMed:30071275) (By similarity).
May protect neurons from excitotoxic cell death by regulating the synaptic localization of cell surface N-methyl-D-aspartate-type glutamate receptors (NMDARs) and NMDAR-mediated excitatory postsynaptic current (By similarity).
Isoform 4
Displays no 4-phosphatase activity for PtdIns(3,4)P2, Ins(3,4)P2, or Ins(1,3,4)P3.
Biological Process
Inositol phosphate metabolic processTAS:Reactome
Phosphatidylinositol biosynthetic processTAS:Reactome
Signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Early endosome membrane; Recycling endosome membrane; Cell membrane; Nucleus; Cytoplasm; Cell junction, synapse, postsynaptic density. Translocates to the plasma membrane upon EGF stimulation (PubMed:15716355).
Shuttles between the cytoplasm and the nucleus, depending on the cell cycle stage, with highest amounts detected in the nucleus during the G0/G1phase (PubMed:30071275).

Tran, D. M., Yoshioka, N., Bizen, N., Mori-Ochiai, Y., Yano, M., Yanai, S., ... & Takebayashi, H. (2023). Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity. Disease Models & Mechanisms, 16(7).

Hecher, L., Harms, F. L., Lisfeld, J., Alawi, M., Denecke, J., & Kutsche, K. (2023). INPP4A-related genetic and phenotypic spectrum and functional relevance of subcellular targeting of INPP4A isoforms. neurogenetics, 24(2), 79-93.

Tan, H., Tong, X., Gao, Z., Xu, Y., Tan, L., Zhang, W., ... & Xu, Y. (2022). The hMeDIP-Seq identified INPP4A as a novel biomarker for eosinophilic chronic rhinosinusitis with nasal polyps. Epigenomics, 14(12), 757-775.

Zhou, Y., Zhang, T., Yan, Y., You, B., You, Y., Zhang, W., & Chen, J. (2021). MicroRNA-223-3p regulates allergic inflammation by targeting INPP4A. Brazilian Journal of Otorhinolaryngology, 87, 591-600.

Banihashemi, S., Tahmasebi-Birgani, M., Mohammadiasl, J., & Hajjari, M. (2020). Whole exome sequencing identified a novel nonsense INPP4A mutation in a family with intellectual disability. European journal of medical genetics, 63(4), 103846.

Maruyama, N., Umikawa, M., Matsumoto, H., Maruyama, T., Nishihara, K., Nakasone, T., ... & Takaesu, G. (2020). miR-935 inhibits oral squamous cell carcinoma and targets inositol polyphosphate-4-phosphatase type IA (INPP4A). Anticancer Research, 40(11), 6101-6113.

Zhang, M., Tian, H., Li, R., Yan, W., & Xu, R. (2018). MicroRNA-4286 promotes esophageal carcinoma development by targeting INPP4A to evoke the JAK2/STAT3 pathway activation. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 73(6), 342-348.

Wang, R., Wu, Y., Huang, W., & Chen, W. (2018). MicroRNA-940 targets INPP4A or GSK3β and activates the Wnt/β-catenin pathway to regulate the malignant behavior of bladder cancer cells. Oncology Research, 26(1), 145.

Zhang, W., Qiao, B., & Fan, J. (2018). Overexpression of miR-4443 promotes the resistance of non-small cell lung cancer cells to epirubicin by targeting INPP4A and regulating the activation of JAK2/STAT3 pathway. Die Pharmazie-An International Journal of Pharmaceutical Sciences, 73(7), 386-392.

Wang, L., Wang, Y., Duan, C., & Yang, Q. (2018). Inositol phosphatase INPP4A inhibits the apoptosis of in vitro neurons with characteristic of intractable epilepsy by reducing intracellular Ca2+ concentration. International Journal of Clinical and Experimental Pathology, 11(4), 1999.

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For research use only. Not intended for any clinical use.

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