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Mouse Anti-KAT2B Recombinant Antibody (CBT2069) (V2LY-0625-LY1211)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat, Monkey
Clone
CBT2069
Antibody Isotype
IgG1
Application
IHC, ICC, FC

Basic Information

Immunogen
Purified recombinant fragment of human KAT2B (AA: 1-142) expressed in E. Coli.
Host Species
Mouse
Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
IHC-P1:200-1:1,000
ICC1:200-1:1,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Lysine Acetyltransferase 2B
Entrez Gene ID
8850
UniProt ID
Q92831
Function
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation (PubMed:8945521).
Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles (PubMed:8945521).
Also acetylates non-histone proteins, such as ACLY, MAPRE1/EB1, PLK4, RRP9/U3-55K and TBX5 (PubMed:9707565, PubMed:10675335, PubMed:23001180, PubMed:27796307, PubMed:23932781, PubMed:26867678, PubMed:29174768).
Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A (PubMed:8684459).
Acts as a circadian transcriptional coactivator which enhances the activity of the circadian transcriptional activators: NPAS2-ARNTL/BMAL1 and CLOCK-ARNTL/BMAL1 heterodimers (PubMed:14645221).
Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768).
Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307).
Acetylates RRP9/U3-55K, a core subunit of the U3 snoRNP complex, impairing pre-rRNA processing (PubMed:26867678).
Acetylates MAPRE1/EB1, promoting dynamic kinetochore-microtubule interactions in early mitosis (PubMed:23001180).
Also acetylates spermidine (PubMed:27389534).
(Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
Biological Process
Cell cycleIEA:UniProtKB-KW
Cellular response to insulin stimulusManual Assertion Based On ExperimentIDA:BHF-UCL
Chromatin remodelingManual Assertion Based On ExperimentIDA:UniProtKB
Epigenetic maintenance of chromatin in transcription-competent conformationTAS:Reactome
Heart developmentISS:UniProtKB
Histone H3 acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Histone H3-K9 acetylationIEA:Ensembl
Internal peptidyl-lysine acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Limb developmentISS:UniProtKB
N-terminal peptidyl-lysine acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of centriole replicationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of rRNA processingManual Assertion Based On ExperimentIDA:UniProtKB
Peptidyl-lysine acetylationManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of gluconeogenesisIEA:Ensembl
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:BHF-UCL
Protein acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell cycleManual Assertion Based On ExperimentTAS:ProtInc
Regulation of protein ADP-ribosylationManual Assertion Based On ExperimentIDA:BHF-UCL
Rhythmic processIEA:UniProtKB-KW
Cellular Location
Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm. Mainly localizes to the nucleus. Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation. Subcellular location may vary depending upon cell differentiation state. Cytoplasmic at the very stages of keratinocyte differentiation, becomes nuclear at later differentiation stages. Cytoplasmic in basal epithelial cells (undifferentiated cells) and nuclear in parabasal cells (differentiated cells) (PubMed:20940255).
Involvement in disease
Defects in KAT2B has been found in a patient with isolated coloboma, a defect of the eye characterized by the absence of ocular structures due to abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Isolated colobomas may be associated with an abnormally small eye (microphthalmia) or small cornea
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For research use only. Not intended for any clinical use.

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