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Mouse Anti-KCNC4 Recombinant Antibody (A734) (CBMAB-AP11276LY)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
A734
Antibody Isotype
IgG1
Application
ICC/IF, AM, IHC, IP, WB

Basic Information

Immunogen
Synthetic peptide amino acids 175-192 of rat Kv3.4
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Potassium Voltage-Gated Channel Subfamily C Member 4
Introduction
The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]
Entrez Gene ID
Human3749
Mouse99738
Rat684516
UniProt ID
HumanQ03721
MouseQ8R1C0
RatQ63734
Alternative Names
Potassium Voltage-Gated Channel Subfamily C Member 4; Potassium Channel, Voltage Gated Shaw Related Subfamily C, Member 4; Potassium Voltage-Gated Channel, Shaw-Related Subfamily, Member 4; C1orf30; KSHIIIC; Voltage-Gated Potassium Channel Subunit KV3.4;
Function
This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.
Biological Process
Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Protein homooligomerizationIEA:InterPro
Regulation of ion transmembrane transportIEA:UniProtKB-KW
Cellular Location
Membrane
Topology
Cytoplasmic: 1-226
Helical: 227-247
Helical: 278-298
Cytoplasmic: 299-312
Helical: 313-333
Helical: 345-364
Cytoplasmic: 365-380
Helical: 381-401
Helical: 452-472
Cytoplasmic: 473-635
PTM
Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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