KCNC4

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

Full Name

Potassium Voltage-Gated Channel Subfamily C Member 4

Function

This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient.

Biological Process

Chemical synaptic transmissionManual Assertion Based On ExperimentTAS:ProtInc
Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Potassium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Protein homooligomerizationIEA:InterPro
Regulation of ion transmembrane transportIEA:UniProtKB-KW

Cellular Location

Membrane

Topology

Cytoplasmic: 1-226
Helical: 227-247
Helical: 278-298
Cytoplasmic: 299-312
Helical: 313-333
Helical: 345-364
Cytoplasmic: 365-380
Helical: 381-401
Helical: 452-472
Cytoplasmic: 473-635

PTM

Phosphorylation of serine residues in the inactivation gate inhibits rapid channel closure.