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Mouse Anti-ASTN1 Recombinant Antibody (H-9) (CBMAB-1154-CN)

This product is a mouse antibody that recognizes ASTN1 of human. The antibody H-9 can be used for immunoassay techniques such as: WB, ELISA, IF, IP.
See all ASTN1 antibodies
Published Data
Mouse Anti-ASTN1 Recombinant Antibody (H-9) CBMAB-1154-CN in WB
Protein expression levels in 5 liver cancer cell lines as well as the MIHA normal liver cell line. ...View More
Chen, Q. F., Shi, F., Huang, T., Huang, C., Shen, L., Wu, P., & Li, W. (2020). ASTN1 is associated with immune infiltrates in hepatocellular carcinoma, and inhibits the migratory and invasive capacity of liver cancer via the Wnt/β‑catenin signaling pathway. Oncology Reports, 44(4), 1425-1440.
Mouse Anti-ASTN1 Recombinant Antibody (H-9) CBMAB-1154-CN in IHC
Immunohistochemistry staining of HCC tissues. T, tumor; NT, nontumor tissue. ...View More
Chen, Q. F., Shi, F., Huang, T., Huang, C., Shen, L., Wu, P., & Li, W. (2020). ASTN1 is associated with immune infiltrates in hepatocellular carcinoma, and inhibits the migratory and invasive capacity of liver cancer via the Wnt/β‑catenin signaling pathway. Oncology Reports, 44(4), 1425-1440.
Mouse Anti-ASTN1 Recombinant Antibody (H-9) CBMAB-1154-CN in IF
Immunofluorescence staining was performed to assess ASTN1 and β-catenin expression in xenografts. ASTN1 expression was increased and β-catenin expression was decreased in the ASTN1-overexpressing group. ...View More
Chen, Q. F., Shi, F., Huang, T., Huang, C., Shen, L., Wu, P., & Li, W. (2020). ASTN1 is associated with immune infiltrates in hepatocellular carcinoma, and inhibits the migratory and invasive capacity of liver cancer via the Wnt/β‑catenin signaling pathway. Oncology Reports, 44(4), 1425-1440.

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
H-9
Antibody Isotype
IgG1, κ
Application
WB, ELISA, IF, IP

Basic Information

Immunogen
Amino acids 736-938 mapping within an internal region of Astrotactin of human origin.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
WB1:100-1:1,000
IP1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)1:50-1:500
ELISA1:100-1:1,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 0.1% gelatin
Preservative
< 0.1% sodium azide
Concentration
0.2 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Astrotactin 1
Introduction
Astrotactin is a neuronal adhesion molecule required for glial-guided migration of young postmitotic neuroblasts in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum, and olfactory bulb. The protein is a neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. It is required for normal rate of migration of granule cells during brain development and for normal cerebellum development.
Entrez Gene ID
Human460
Mouse11899
Rat304900
UniProt ID
HumanO14525
MouseQ61137
RatA0A1S3F323
Alternative Names
ASTN
Function
Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development.
Biological Process
Locomotory behavior Source: Ensembl
Neuron cell-cell adhesion Source: GO_Central
Neuron migration Source: GO_Central
Cellular Location
Endosome; Cell membrane; Perikaryon; Clathrin-coated vesicle. Detected close to the anterior pole and at the base of the leading process in migrating neurons. Is internalized from the membrane via clathrin-coated vesicles and endosomes, and recycled to the anterior pole of the migrating cell.
Topology
Extracellular: 22-153 aa
Helical: 154-174 aa
Cytoplasmic: 175-383 aa
Helical: 384-402 aa
Extracellular: 403-1302 aa
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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