ASTN1

Astrotactin is a neuronal adhesion molecule required for glial-guided migration of young postmitotic neuroblasts in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum, and olfactory bulb (Fink et al., 1995).[supplied by OMIM

Full Name

Astrotactin 1

Function

Neuronal adhesion molecule that is required for normal migration of young postmitotic neuroblasts along glial fibers, especially in the cerebellum. Required for normal rate of migration of granule cells during brain development and for normal cerebellum development.

Biological Process

Locomotory behavior Source: Ensembl
Neuron cell-cell adhesion Source: GO_Central
Neuron migration Source: GO_Central

Cellular Location

Endosome; Cell membrane; Perikaryon; Clathrin-coated vesicle. Detected close to the anterior pole and at the base of the leading process in migrating neurons. Is internalized from the membrane via clathrin-coated vesicles and endosomes, and recycled to the anterior pole of the migrating cell.

Topology

Extracellular: 22-153 aa
Helical: 154-174 aa
Cytoplasmic: 175-383 aa
Helical: 384-402 aa
Extracellular: 403-1302 aa