Rat Anti-4-1BB Recombinant Antibody (V2-1558) (CBMAB-0953-LY)

Name: Rat Anti-4-1BB Recombinant Antibody (V2-1558)
SKU: CBMAB-0953-LY
Rating: 5 (1 reviews)

See all 4-1BB antibodies

Compare Online Inquiry

Published Data

Rat Anti-4-1BB Recombinant Antibody (LOB12.3) (CBMAB-0953-LY) in IHC

Distinct activity and toxicity profiles of anti-4-1BB Abs. a WT Balb/c (n = 4-5/group) or b B6 mice (n = 5/group) were injected subcutaneously with 1 × 106 (a) CT-26 (b) B16-OVA cells, then 200 μg of anti-4-1BB (3H3 or LOB12.3) or control IgG was administered on days 9, 16, and 23. Tumor growth was measured twice a week. c, d Twenty-one days after the first treatment, serum ALT levels in a, b were measured e Naive Balb/c (n = 4/group) or f B6 mice (n = 4/group) were treated with 200 μg of anti-4-1BB (3H3 or LOB12.3) or control IgG on days 0, 7, and 14, and serum ALT levels were measured on day 21. g Same as in e, f liver tissue was stained by HE. Mean ± SEM are shown. *p < 0.05, **p < 0.01 compared with control group or as indicated. Scale bar: 50 µm ...View More

Qi, X., Li, F., Wu, Y., Cheng, C., Han, P., Wang, J., & Yang, X. (2019). Optimization of 4-1BB antibody for cancer immunotherapy by balancing agonistic strength with FcγR affinity. Nature communications, 10(1), 2141.

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rat

Clone

V2-1558

Application

Activation

Immunogen

Mouse CD137 human Fc fusion protein.

Specificity

Mouse

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Endotoxin

<2EU/mg

Format

Liquid

Buffer

PBS, pH 8.0

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Introduction

Receptor for TNFSF9/4-1BBL. Possibly active during T cell activation.

Entrez Gene ID

21942

UniProt ID

P20334

Alternative Names

ILA; Ly63; Tnfrsf9; Cd137; CDw137; AA408498; AI325004; A930040I11Rik

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Rat Anti-4-1BB Recombinant Antibody (V2-1558)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry