Rabbit Anti-KCND1 Recombinant Antibody (EG1750) (CBMAB-EN2089-LY)

The product is antibody recognizes KCND1. The antibody EG1750 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:20000.
See all KCND1 antibodies

Datasheet

Summary

Host Animal

Rabbit

Specificity

Human, Mouse

Clone

EG1750

Antibody Isotype

IgG

Application

WB: 1:500~1:1000 ELISA: 1:20000

Basic Information

Immunogen

The antibody was produced against synthesized peptide derived from C-terminal of human KCND1.

Specificity

Human, Mouse

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

potassium voltage-gated channel subfamily D member 1

Introduction

This gene encodes a multipass membrane protein that comprises the pore subunit of the voltage-gated A-type potassium channel, which functions in the repolarization of membrane action potentials. Activity of voltage-gated potassium channels is important in a number of physiological processes, among them the regulation of neurotransmitter release, heart rate, insulin secretion, and smooth muscle contraction.

Entrez Gene ID

Human	3750
Mouse	16506

UniProt ID

Human	Q9NSA2
Mouse	Q03719

Alternative Names

KV4.1

Function

Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.

Biological Process

Potassium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Protein homooligomerizationIEA:InterPro
Regulation of ion transmembrane transportIEA:UniProtKB-KW

Cellular Location

Membrane; Cell projection, dendrite

Topology

Cytoplasmic: 1-184
Helical: 185-205
Helical: 227-247
Cytoplasmic: 248-261
Helical: 262-282
Helical: 292-312
Cytoplasmic: 313-325
Helical: 326-346
Pore-forming: 365-385
Helical: 387-407
Cytoplasmic: 408-647

References

Yang, R., Li, L., Hou, Y., Li, Y., Zhang, J., Yang, N., ... & Shan, H. (2023). Long non-coding RNA KCND1 protects hearts from hypertrophy by targeting YBX1. Cell Death & Disease, 14(5), 344.

Hou, Y., Li, L., Yang, R., Li, Y., Zhang, J., Yang, N., ... & Shan, H. (2022). Long non-coding RNA KCND1 protects hearts from hypertrophy by targeting YBX1.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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SDS
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