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Mouse Anti-KIF1B Recombinant Antibody (1521CT681.1.2) (CBMAB-K0850-LY)

This product is antibody recognizes KIF1B. The antibody 1521CT681.1.2 immunoassay techniques such as: ELISA, WB.
See all KIF1B antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1521CT681.1.2
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.09% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Kinesin Family Member 1B
Introduction
This gene encodes a motor protein that transports mitochondria and synaptic vesicle precursors. Mutations in this gene cause Charcot-Marie-Tooth disease, type 2A1. [provided by RefSeq, Jul 2008]
Entrez Gene ID
23095
UniProt ID
O60333
Alternative Names
Kinesin Family Member 1B; KLP; Kinesin Superfamily Protein KIF1B; Kinesin-Like Protein KIF1B; KIAA0591; KIAA1448;
Function
Motor for anterograde transport of mitochondria. Has a microtubule plus end-directed motility. Isoform 2 is required for induction of neuronal apoptosis.
Isoform 1 mediates the transport of synaptic vesicles in neuronal cells.
Biological Process
Anterograde axonal transportISS:UniProtKB
Apoptotic processIEA:UniProtKB-KW
Cytoskeleton-dependent intracellular transportISS:UniProtKB
Microtubule-based movementISS:UniProtKB
Neuromuscular synaptic transmissionISS:UniProtKB
Neuron-neuron synaptic transmissionISS:UniProtKB
Vesicle-mediated transportManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm, cytoskeleton; Mitochondrion; Cell projection, axon
Isoform 1: Cytoplasmic vesicle, secretory vesicle, synaptic vesicle
Involvement in disease
Charcot-Marie-Tooth disease 2A1 (CMT2A1):
A dominant axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy.
Neuroblastoma 1 (NBLST1):
A common neoplasm of early childhood arising from embryonic cells that form the primitive neural crest and give rise to the adrenal medulla and the sympathetic nervous system.
Pheochromocytoma (PCC):
A catecholamine-producing tumor of chromaffin tissue of the adrenal medulla or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of epinephrine and norepinephrine, is hypertension, which may be persistent or intermittent.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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