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Mouse Anti-KLHL41 Recombinant Antibody (1H3) (CBMAB-K0459-LY)

This product is antibody recognizes KLHL41. The antibody 1H3 immunoassay techniques such as: ELISA, WB.
See all KLHL41 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1H3
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
KBTBD10 (205 a.a. ~ 304 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.Immunogen sequence: RTDKENRVKN LSEVFDCIRF RLMTEKYFKD HVEKDDIIKS NPDLQKKIKV LKDAFAGKLP EPSKNAAKTG AGEVNGDVGD EDLLPGYLND IPRHGMFVKD
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
KLHL41
Introduction
This gene is a member of the kelch-like family. The encoded protein contains a BACK domain, a BTB/POZ domain, and 5 Kelch repeats. This protein is thought to function in skeletal muscle development and maintenance. Mutations in this gene have been associated with nemaline myopathy (NM), a rare congenital muscle disorder.
Entrez Gene ID
10324
UniProt ID
O60662
Alternative Names
Krp1; KBTBD10; SARCOSIN
Function
Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells.
Biological Process
Myofibril assemblyISS:UniProtKB
Protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of myoblast differentiationISS:UniProtKB
Regulation of myoblast proliferationISS:UniProtKB
Regulation of skeletal muscle cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Sarcomere organizationIEA:InterPro
Skeletal muscle cell differentiationISS:UniProtKB
Skeletal muscle fiber developmentIEA:InterPro
Striated muscle contractionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm; Cytoplasm, cytoskeleton; Cell projection, pseudopodium; Cell projection, ruffle; Cytoplasm, myofibril, sarcomere, M line; Sarcoplasmic reticulum membrane; Endoplasmic reticulum membrane. Predominantly cytoplasmic but can colocalize with F-actin at the membrane ruffle-like structures at the tips of transformation-specific pseudopodia.
Involvement in disease
Nemaline myopathy 9 (NEM9):
An autosomal recessive form of nemaline myopathy. Nemaline myopathies are muscular disorders characterized by muscle weakness of varying severity and onset, and abnormal thread-like or rod-shaped structures in muscle fibers on histologic examination. NEM9 phenotype is highly variable, ranging from death in infancy due to lack of antigravity movements, to slowly progressive distal muscle weakness with preserved ambulation later in childhood.
PTM
Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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