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Rat Anti-Klre1 Recombinant Antibody (854929) (CBMAB-K0176-LY)

This product is antibody recognizes Klre1. The antibody 854929 immunoassay techniques such as: FC, CyTOF.
See all Klre1 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
854929
Antibody Isotype
IgG2b
Application
FC, CyTOF

Basic Information

Immunogen
Chinese hamster ovary cell line, CHO derived recombinant mouse Klre-1, Lys94-Lys226
Specificity
Mouse
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
killer cell lectin-like receptor family E member 1
Entrez Gene ID
243655
UniProt ID
Q8CJC7
Alternative Names
NKG2I; Klre-1
Function
Lectin-like receptor for natural killer (NK) cells (PubMed:14707119, PubMed:15069013, PubMed:18713988).
Can either inhibit or activate NK cell cytotoxic activity, depending on its binding partner (PubMed:14707119, PubMed:15069013, PubMed:18713988).
Heterodimer formation with KLRI1 mediates NK cell inhibition whereas heterodimer formation with KLRI2 mediates NK cell activation (PubMed:18713988).
Plays a role in allogeneic recognition by the immune system (PubMed:14707119, PubMed:15069013).
Biological Process
Natural killer cell activationManual Assertion Based On ExperimentIDA:MGI
Negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetISO:MGI
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:MGI
Positive regulation of natural killer cell mediated cytotoxicityManual Assertion Based On ExperimentIMP:MGI
Stimulatory C-type lectin receptor signaling pathwayManual Assertion Based On ExperimentIDA:MGI
Cellular Location
Cell membrane
Topology
Cytoplasmic: 1-68
Helical: 69-89
Extracellular: 90-226
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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