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Mouse Anti-L. monocytogenes hly Recombinant Antibody (CBMC-C1101) (CBMAB-V208-1766-CQ)

This product is a mouse antibody that recognizes L. monocytogenes hly. The antibody CBMC-C1101 can be used for immunoassay techniques such as: WB, ELISA.
See all L. monocytogenes hly antibodies

Summary

Host Animal
Mouse
Specificity
L. monocytogenes
Clone
CBMC-C1101
Antibody Isotype
IgG1
Application
WB, ELISA

Basic Information

Specificity
L. monocytogenes
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
vacuolar carboxypeptidase Y
Introduction
Sulfhydryl-activated pore-forming toxin, which is a major virulence factor required for the escape of bacteria from phagosomal vacuoles and entry into the host cytosol. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Listeriolysin O activates mitogen-activated protein (MAP) kinase activity in host cells, most likely as a result of the permeabilization of the host cell membrane. Also induces a proteasome-independent degradation of UBE2I (the SUMO-conjugating enzyme UBC9) and a proteasome-dependent degradation of some sumoylated proteins. Finally, is necessary and sufficient for spacious Listeria-containing phagosomes (SLAPs) formation, suggesting a role for listeriolysin O in promoting L.monocytogenes replication in vacuoles, leading to persistent infection.
Entrez Gene ID
987033
UniProt ID
P13128
Alternative Names
listeriolysin O precursor; hly; listeriolysin O precursor
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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