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Mouse Anti-LAD1 Recombinant Antibody (CBYJL-1047) (CBMAB-L0466-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Ladinin 1 (LAD1). The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all LAD1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1047
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa 418-517 from human LAD1 (NP_005549.2) with GST tag. MW of the GST tag alone is 26kD.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.2
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 418-517

Target

Full Name
ladinin 1
Introduction
Ladinin 1 (LAD1) may be an anchoring filament that is a component of basement membranes. Ladinin 1 may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. Diseases associated with LAD1 include Epidermolysis Bullosa and Linear Iga Disease.
Entrez Gene ID
3898
UniProt ID
O00515
Alternative Names
LadA
Function
Anchoring filament protein which is a component of the basement membrane zone.
Cellular Location
Secreted, extracellular space, extracellular matrix, basement membrane

Hu, L., Liu, Y., Fu, C., Zhao, J., Cui, Q., Sun, Q., ... & Yang, W. (2023). The Tumorigenic Effect of the High Expression of Ladinin-1 in Lung Adenocarcinoma and Its Potential as a Therapeutic Target. Molecules, 28(3), 1103.

Liu, X., Wang, X., & Zheng, Q. (2023). The Role of Ladinin-1 in Cancer. Highlights in Science, Engineering and Technology, 54, 31-36.

Chang, C. Y., Huang, Y. C., Chiang, H. H., Wu, Y. Y., Wu, K. L., Chang, Y. Y., ... & Hsu, Y. L. (2023). Ladinin 1 Shortens Survival via Promoting Proliferation and Enhancing Invasiveness in Lung Adenocarcinoma. International Journal of Molecular Sciences, 24(1), 431.

Jiang, Y., Feng, Y., Huang, J., Huang, Z., Tan, R., Li, T., ... & Yang, Z. (2023). LAD1 promotes malignant progression by diminishing ubiquitin-dependent degradation of vimentin in gastric cancer. Journal of Translational Medicine, 21(1), 632.

Yuan, K., Zhang, Y., Yu, Y., Xu, Y., & Xian, S. (2023). Anchoring Filament Protein Ladinin-1 is an Immunosuppressive Microenvironment and Cold Tumor Correlated Prognosticator in Lung Adenocarcinoma. Biochemical Genetics, 1-30.

Li, J., Wang, Z., & Tie, C. (2021). High expression of ladinin-1 (LAD1) predicts adverse outcomes: a new candidate docetaxel resistance gene for prostatic cancer (PCa). Bioengineered, 12(1), 5749-5759.

Moon, B., Yang, S. J., Park, S. M., Lee, S. H., Song, K. S., Jeong, E. J., ... & Kim, J. A. (2020). LAD1 expression is associated with the metastatic potential of colorectal cancer cells. BMC cancer, 20, 1-12.

Abe, T., Yamazaki, M., Maruyama, S., & Ajioka, Y. (2019). Ladinin-1 is involved in cell motility and proliferation of oral squamous cell carcinoma cells. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, 128(1), e81-e82.

Roth, L., Srivastava, S., Lindzen, M., Sas-Chen, A., Sheffer, M., Lauriola, M., ... & Yarden, Y. (2018). SILAC identifies LAD1 as a filamin-binding regulator of actin dynamics in response to EGF and a marker of aggressive breast tumors. Science signaling, 11(515), eaan0949.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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