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Mouse Anti-LGR6 Recombinant Antibody (2A3) (CBMAB-L1367-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Leucine Rich Repeat Containing G Protein-Coupled Receptor 6 (LGR6). The antibody can be used for immunoassay techniques, such as IF, WB.
See all LGR6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
2A3
Antibody Isotype
IgG1
Application
IF, WB

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 25-250 of human LGR6(NP_001017403) produced in HEK293T cell.
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 25-250

Target

Full Name
leucine rich repeat containing G protein-coupled receptor 6
Introduction
LGR6 is a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. LGR6 is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene lead to multiple transcript variants.
Entrez Gene ID
59352
UniProt ID
Q9HBX8
Alternative Names
GPCR; VTS20631
Function
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor.
Biological Process
Axon guidanceManual Assertion Based On ExperimentIBA:GO_Central
Bone regenerationIEA:Ensembl
G protein-coupled receptor signaling pathwayIEA:UniProtKB-KW
Negative chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of canonical Wnt signaling pathwayISS:UniProtKB
Positive regulation of cell migrationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Wnt signaling pathwayIEA:UniProtKB-KW
Cellular Location
Cell membrane
Topology
Extracellular: 25-567
Helical: 568-588
Cytoplasmic: 589-598
Helical: 599-619
Extracellular: 620-644
Helical: 645-665
Cytoplasmic: 666-687
Helical: 688-708
Extracellular: 709-727
Helical: 728-748
Cytoplasmic: 749-774
Helical: 775-795
Extracellular: 796-809
Helical: 810-830
Cytoplasmic: 831-967
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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