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Mouse Anti-LHCGR Recombinant Antibody (LHCGR/1415) (CBMAB-L1426-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Luteinizing Hormone/Choriogonadotropin Receptor (LHCGR). The antibody can be used for immunoassay techniques, such as WB, FC, ICC, IF.
See all LHCGR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
LHCGR/1415
Antibody Isotype
IgG1, κ
Application
WB, FC, ICC, IF

Basic Information

Immunogen
Purified recombinant N-terminal fragment of human LHCGR (exact sequence is proprietary).
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
N-terminus

Target

Full Name
lutropin-choriogonadotropic hormone receptor precursor
Introduction
LHCGR is the receptor for both luteinizing hormone and choriogonadotropin. LHCGR belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. Diseases associated with LHCGR include Precocious Puberty, Male-Limited and Leydig Cell Hypoplasia, Type I. Among its related pathways are Ovarian steroidogenesis and Signaling by GPCR. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and luteinizing hormone receptor activity. An important paralog of this gene is FSHR.
Entrez Gene ID
3973
UniProt ID
P22888
Alternative Names
HHG; LHR; LCGR; LGR2; ULG5; LHRHR; LSH-R; LH/CGR; LH/CG-R
Function
Receptor for lutropin-choriogonadotropic hormone (PubMed:11847099).
The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11847099).
Biological Process
Activation of adenylate cyclase activityISS:BHF-UCL
Adenylate cyclase-activating G protein-coupled receptor signaling pathwayISS:BHF-UCL
Cellular response to gonadotropin stimulusISS:BHF-UCL
Cellular response to luteinizing hormone stimulusManual Assertion Based On ExperimentIMP:UniProtKB
CognitionManual Assertion Based On ExperimentIMP:UniProtKB
G protein-coupled receptor signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerManual Assertion Based On ExperimentTAS:ProtInc
Hormone-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Luteinizing hormone signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Male genitalia developmentManual Assertion Based On ExperimentTAS:ProtInc
Male gonad developmentManual Assertion Based On ExperimentIBA:GO_Central
Ovarian follicle developmentManual Assertion Based On ExperimentIBA:GO_Central
Ovulation cycle processManual Assertion Based On ExperimentIBA:GO_Central
Phospholipase C-activating G protein-coupled receptor signaling pathwayISS:BHF-UCL
Positive regulation of inositol trisphosphate biosynthetic processISS:BHF-UCL
Cellular Location
Cell membrane
Involvement in disease
Familial male precocious puberty (FMPP):
In FMPP the receptor is constitutively activated.
Luteinizing hormone resistance (LHR):
An autosomal recessive disorder characterized by unresponsiveness to luteinizing hormone, defective sexual development in males, and defective follicular development and ovulation, amenorrhea and infertility in females. Two forms of the disorder have been defined in males. Type 1 is a severe form characterized by complete 46,XY male pseudohermaphroditism, low testosterone and high luteinizing hormone levels, total lack of responsiveness to luteinizing and chorionic gonadotropin hormones, lack of breast development, and absent development of secondary male sex characteristics. Type 2, a milder form, displays a broader range of phenotypic expression ranging from micropenis to severe hypospadias.
Topology
Extracellular: 27-363
Helical: 364-385
Cytoplasmic: 386-395
Helical: 396-416
Extracellular: 417-439
Helical: 440-462
Cytoplasmic: 463-482
Helical: 483-505
Extracellular: 506-525
Helical: 526-549
Cytoplasmic: 550-570
Helical: 571-594
Extracellular: 595-605
Helical: 606-627
Cytoplasmic: 628-699
PTM
Sulfated.

Xie, Y., Guo, W., Shen, X., Yu, W., Kuang, Y., Chen, Q., ... & Wang, L. (2023). A delayed ovulation of progestin-primed ovarian stimulation (PPOS) by downregulating the LHCGR/PGR pathway. Iscience, 26(8).

Makhdoomi, M. J., Shah, I. A., Rashid, R., Rashid, A., Singh, S., Shah, Z. A., & Ganie, M. A. (2023). Effect modification of LHCGR gene variant (rs2293275) on clinico-biochemical profile, and levels of luteinizing hormone in polycystic ovary syndrome patients. Biochemical Genetics, 1-15.

Alarcón-Granados, M. C., Moreno-Ortiz, H., Rondón-Lagos, M., Camargo-Villalba, G. E., & Forero-Castro, M. (2022). Study of LHCGR gene variants in a sample of colombian women with polycystic ovarian syndrome: A pilot study. Journal of King Saud University-Science, 34(6), 102202.

Singh, S., Kaur, M., Kaur, R., Beri, A., & Kaur, A. (2022). Association analysis of LHCGR variants and polycystic ovary syndrome in Punjab: a case–control approach. BMC Endocrine Disorders, 22(1), 335.

Flippo, C., Kolli, V., Andrew, M., Berger, S., Bhatti, T., Boyce, A. M., ... & Dauber, A. (2022). Precocious Puberty in a Boy With Bilateral Leydig Cell Tumors due to a Somatic Gain-of-Function LHCGR Variant. Journal of the Endocrine Society, 6(10), bvac127.

Widmer, S., Seefried, F. R., von Rohr, P., Häfliger, I. M., Spengeler, M., & Drögemüller, C. (2021). A major QTL at the LHCGR/FSHR locus for multiple birth in Holstein cattle. Genetics selection evolution, 53(1), 57.

Ga, R., Cheemakurthi, R., Kalagara, M., Prathigudupu, K., Balabomma, K. L., Mahapatro, P., ... & Muvvala, S. P. R. (2021). Effect of LHCGR gene polymorphism (rs2293275) on LH supplementation protocol outcomes in second IVF cycles: A retrospective study. Frontiers in Endocrinology, 12, 628169.

Wohlres-Viana, S., Arashiro, E. K. N., Minare, T. P., Fernandes, C. A. C., Grazia, J. G. V., Siqueira, L. G. B., ... & Viana, J. H. M. (2019). Differential expression of LHCGR and its isoforms is associated to the variability in superovulation responses of Gir cattle. Theriogenology, 126, 68-74.

Kawai, T., Richards, J. S., & Shimada, M. (2018). The cell type–specific expression of Lhcgr in mouse ovarian cells: evidence for a DNA-demethylation–dependent mechanism. Endocrinology, 159(5), 2062-2074.

Ponomarenko, I. V., Polonikov, A. V., & Churnosov, M. I. (2018). Polymorphic LHCGR gene loci associated with the development of uterine fibroids. Obstetrics and Gynecology, (10), 86-91.

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For research use only. Not intended for any clinical use.

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