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Rabbit Anti-LIM2 Monoclonal Antibody (EPR16947) (CBMAB-1380-YC)

Provided herein is a rabbit monoclonal antibody against Human LIM2. The antibody, clone EPR16947, can be used for immunoassay techniques, such as WB.
See all LIM2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
EPR16947
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Synthetic peptide within Human LIM2 aa 50-150.
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
lens intrinsic membrane protein 2
Introduction
LIM2 is an eye lens-specific protein found at the junctions of lens fiber cells, where it may contribute to cell junctional organization. LIM2 acts as a receptor for calmodulin, and may play an important role in both lens development and cataractogenesis. Mutations in LIM2 have been associated with cataract formation.
Entrez Gene ID
Human3982
Mouse233187
Rat114903
UniProt ID
HumanP55344
MouseP56563
RatP54825
Alternative Names
MP17; MP19; CTRCT19
Function
Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis.
Biological Process
Cell-cell junction assembly1 PublicationNAS:UniProtKB
Lens development in camera-type eyeIEA:Ensembl
Cellular Location
Membrane
Involvement in disease
Cataract, multiple types 19 (CTRCT19):
An opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function.
Topology
Cytoplasmic: 1-3
Helical: 4-24
Extracellular: 25-66
Helical: 67-87
Cytoplasmic: 88-98
Helical: 99-119
Extracellular: 120-140
Helical: 141-161
Cytoplasmic: 162-173
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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