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Mouse Anti-LRP1B Recombinant Antibody (CBYJL-1970) (CBMAB-L2050-YJ)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-1970
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Recombinant Protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Preservative
0.09% (W/V) Sodium Azide
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
LDL receptor related protein 1B
Introduction
LRP1B is a member of the low density lipoprotein (LDL) receptor family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands. Disruption of this gene has been reported in several types of cancer.
Entrez Gene ID
53353
UniProt ID
Q9NZR2
Alternative Names
LRP-1B; LRPDIT; LRP-DIT; low-density lipoprotein receptor-related protein 1B; LRP-deleted in tumors; low density lipoprotein receptor related protein-deleted in tumor; low density lipoprotein receptor-related protein 1B; low density lipoprotein-related protein 1B (deleted in tumors)
Function
Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.
Biological Process
Protein transportManual Assertion Based On ExperimentTAS:ProtInc
Receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Topology
Extracellular: 25-4444
Helical: 4445-4467
Cytoplasmic: 4468-4599
More Infomation

Holm, B., Barsuhn, S., Behrens, H. M., Krüger, S., & Röcken, C. (2023). The tumor biological significance of RNF43 and LRP1B in gastric cancer is complex and context-dependent. Scientific Reports, 13(1), 3191.

Cheng, Y., Tang, R., Li, X., Wang, B., Cheng, Y., Xiao, S., ... & Zhu, Y. (2022). LRP1B is a potential biomarker for tumor immunogenicity and prognosis of HCC patients receiving ICI treatment. Journal of Hepatocellular Carcinoma, 203-220.

Zhu, M., Zhang, L., Cui, H., Zhao, Q., Wang, H., Zhai, B., ... & Jiang, Z. (2022). Co-mutation of FAT3 and LRP1B in lung adenocarcinoma defines a unique subset correlated with the efficacy of immunotherapy. Frontiers in immunology, 12, 800951.

Liu, F., Hou, W., Liang, J., Zhu, L., & Luo, C. (2021). LRP1B mutation: a novel independent prognostic factor and a predictive tumor mutation burden in hepatocellular carcinoma. Journal of Cancer, 12(13), 4039.

Príncipe, C., Dionísio de Sousa, I. J., Prazeres, H., Soares, P., & Lima, R. T. (2021). LRP1B: a giant lost in cancer translation. Pharmaceuticals, 14(9), 836.

Brown, L. C., Tucker, M. D., Sedhom, R., Schwartz, E. B., Zhu, J., Kao, C., ... & Armstrong, A. J. (2021). LRP1B mutations are associated with favorable outcomes to immune checkpoint inhibitors across multiple cancer types. Journal for immunotherapy of cancer, 9(3).

Wang, L., Yan, K., He, X., Zhu, H., Song, J., Chen, S., ... & Wang, L. (2021). LRP1B or TP53 mutations are associated with higher tumor mutational burden and worse survival in hepatocellular carcinoma. Journal of Cancer, 12(1), 217.

Li, M., Hu, J., Jin, R., Cheng, H., Chen, H., Li, L., & Guo, K. (2020). Effects of LRP1B regulated by HSF1 on lipid metabolism in hepatocellular carcinoma. Journal of Hepatocellular Carcinoma, 361-376.

Chen, H., Chong, W., Wu, Q., Yao, Y., Mao, M., & Wang, X. (2019). Association of LRP1B mutation with tumor mutation burden and outcomes in melanoma and non-small cell lung cancer patients treated with immune check-point blockades. Frontiers in immunology, 10, 1113.

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For research use only. Not intended for any clinical use.

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