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Mouse Anti-LRP1B Recombinant Antibody (CBT4008) (V2LY-0625-LY1155)

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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT4008
Antibody Isotype
IgG2a
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human LRP1B (AA: extra 25-161) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
LDL receptor related protein 1B
Entrez Gene ID
UniProt ID
Function
Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.
Biological Process
Protein transportManual Assertion Based On ExperimentTAS:ProtInc
Receptor-mediated endocytosisManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Topology
Extracellular: 25-4444
Helical: 4445-4467
Cytoplasmic: 4468-4599
More Infomation

Holm, B., Barsuhn, S., Behrens, H. M., Krüger, S., & Röcken, C. (2023). The tumor biological significance of RNF43 and LRP1B in gastric cancer is complex and context-dependent. Scientific Reports, 13(1), 3191.

Cheng, Y., Tang, R., Li, X., Wang, B., Cheng, Y., Xiao, S., ... & Zhu, Y. (2022). LRP1B is a potential biomarker for tumor immunogenicity and prognosis of HCC patients receiving ICI treatment. Journal of Hepatocellular Carcinoma, 203-220.

Zhu, M., Zhang, L., Cui, H., Zhao, Q., Wang, H., Zhai, B., ... & Jiang, Z. (2022). Co-mutation of FAT3 and LRP1B in lung adenocarcinoma defines a unique subset correlated with the efficacy of immunotherapy. Frontiers in immunology, 12, 800951.

Liu, F., Hou, W., Liang, J., Zhu, L., & Luo, C. (2021). LRP1B mutation: a novel independent prognostic factor and a predictive tumor mutation burden in hepatocellular carcinoma. Journal of Cancer, 12(13), 4039.

Príncipe, C., Dionísio de Sousa, I. J., Prazeres, H., Soares, P., & Lima, R. T. (2021). LRP1B: a giant lost in cancer translation. Pharmaceuticals, 14(9), 836.

Brown, L. C., Tucker, M. D., Sedhom, R., Schwartz, E. B., Zhu, J., Kao, C., ... & Armstrong, A. J. (2021). LRP1B mutations are associated with favorable outcomes to immune checkpoint inhibitors across multiple cancer types. Journal for immunotherapy of cancer, 9(3).

Wang, L., Yan, K., He, X., Zhu, H., Song, J., Chen, S., ... & Wang, L. (2021). LRP1B or TP53 mutations are associated with higher tumor mutational burden and worse survival in hepatocellular carcinoma. Journal of Cancer, 12(1), 217.

Li, M., Hu, J., Jin, R., Cheng, H., Chen, H., Li, L., & Guo, K. (2020). Effects of LRP1B regulated by HSF1 on lipid metabolism in hepatocellular carcinoma. Journal of Hepatocellular Carcinoma, 361-376.

Chen, H., Chong, W., Wu, Q., Yao, Y., Mao, M., & Wang, X. (2019). Association of LRP1B mutation with tumor mutation burden and outcomes in melanoma and non-small cell lung cancer patients treated with immune check-point blockades. Frontiers in immunology, 10, 1113.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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