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Mouse Anti-LZTL1 Recombinant Antibody (CBYCL-613) (CBMAB-L0514-YC)

Provided herein is a Mouse monoclonal antibody against Human LZTL1. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all LZTL1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYCL-613
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Leucine Zipper Transcription Factor Like 1)
Introduction
LZTL1 is a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure.
Entrez Gene ID
54585
UniProt ID
Q9NQ48
Alternative Names
5530402H04Rik; 6130400H19Rik; AI414725; AW048545
Function
Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.
Biological Process
Flagellated sperm motilityIEA:Ensembl
Negative regulation of protein localization to ciliary membraneManual Assertion Based On ExperimentIMP:GO_Central
Negative regulation of protein localization to ciliumManual Assertion Based On ExperimentIMP:GO_Central
SpermatogenesisIEA:Ensembl
Cellular Location
Cytoplasm
Involvement in disease
Bardet-Biedl syndrome 17 (BBS17):
A syndrome characterized by usually severe pigmentary retinopathy, early-onset obesity, polydactyly, hypogenitalism, renal malformation and mental retardation. Secondary features include diabetes mellitus, hypertension and congenital heart disease. Bardet-Biedl syndrome inheritance is autosomal recessive, but three mutated alleles (two at one locus, and a third at a second locus) may be required for clinical manifestation of some forms of the disease.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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