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Mouse Anti-MYBBP1A (AA 1104-1328) Recombinant Antibody (CBFYM-2869) (CBMAB-M3063-FY)

This product is mouse antibody that recognizes MYBBP1A. The antibody CBFYM-2869 can be used for immunoassay techniques such as: WB, ELISA.
See all MYBBP1A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-2869
Antibody Isotype
IgG1, k
Application
WB, ELISA

Basic Information

Immunogen
Recombinant protein between 1104-1328 amino acids from human MYBBP1A
Specificity
Human
Antibody Isotype
IgG1, k
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
0.09% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1104-1328

Target

Full Name
MYB BINDING PROTEIN 1A
Introduction
This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
10514
UniProt ID
Q9BQG0
Alternative Names
MYB Binding Protein 1a; MYB Binding Protein (P160) 1a; P53-Activated Protein-2; P160; Myb-Binding Protein 1A; PAP2; Pol5
Function
May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity).

Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity).

Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity).

Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity).

Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309).
Biological Process
Cellular response to glucose starvation Source: UniProtKB
Chromatin remodeling Source: ComplexPortal
Circadian regulation of gene expression Source: UniProtKB
Intrinsic apoptotic signaling pathway by p53 class mediator Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Osteoblast differentiation Source: UniProtKB
Positive regulation of anoikis Source: CACAO
Positive regulation of histone acetylation Source: ComplexPortal
Positive regulation of transcription by RNA polymerase I Source: ComplexPortal
Positive regulation of transcription by RNA polymerase II Source: ComplexPortal
Positive regulation of transcription by RNA polymerase III Source: ComplexPortal
Regulation of G1 to G0 transition Source: UniProtKB
Regulation of transcription, DNA-templated Source: ProtInc
Respiratory electron transport chain Source: Ensembl
Ribosome biogenesis Source: UniProtKB-KW
Cellular Location
Cytoplasm
Nucleus
nucleolus
Note: Shuttles between the nucleus and cytoplasm. Nuclear import may be mediated by KPNA2, while export appears to depend partially on XPO1/CRM1 (By similarity). Predominantly nucleolar.
PTM
Citrullinated by PADI4.

Chen, X., Haribowo, A. G., Baik, A. H., Fossati, A., Stevenson, E., Chen, Y. R., ... & Jain, I. H. (2023). In vivo protein turnover rates in varying oxygen tensions nominate MYBBP1A as a mediator of the hyperoxia response. Science Advances, 9(49), eadj4884.

Abaji, R., Roux, V., Yssaad, I. R., Kalegari, P., Gagné, V., Gioia, R., ... & Krajinovic, M. (2022). Characterization of the impact of the MYBBP1A gene and rs3809849 on asparaginase sensitivity and cellular functions. Pharmacogenomics, 23(7), 415-430.

Hsieh, A., Pitarresi, J. R., Lerner, J., Donahue, G., Hsiehchen, D., Rustgi, A. K., & Zaret, K. (2020). Growth of pancreatic cancers with hemizygous chromosomal 17p loss of MYBBP1A can be preferentially targeted by PARP inhibitors. Science Advances, 6(49), eabc4517.

Felipe-Abrio, B., & Carnero, A. (2020). The tumor suppressor roles of MYBBP1A, a major contributor to metabolism plasticity and stemness. Cancers, 12(1), 254.

Felipe‐Abrio, B., Verdugo‐Sivianes, E. M., & Carnero, A. (2019). c‐MYB‐and PGC1a‐dependent metabolic switch induced by MYBBP1A loss in renal cancer. Molecular oncology, 13(7), 1519-1533.

Felipe-Abrio, B., Verdugo-Sivianes, E. M., Sáez, C., & Carnero, A. (2019). Loss of MYBBP1A induces cancer stem cell activity in renal cancer. Cancers, 11(2), 235.

Weng, X., Wu, J., Lv, Z., Peng, C., Chen, J., Zhang, C., ... & Zheng, S. (2019). Targeting Mybbp1a suppresses HCC progression via inhibiting IGF1/AKT pathway by CpG islands hypo-methylation dependent promotion of IGFBP5. EBioMedicine, 44, 225-236.

Jo, A., Lee, Y., Park, C. H., & Shin, J. H. (2019). Deubiquitinase USP29 governs MYBBP1a in the brains of Parkinson’s disease patients. Journal of clinical medicine, 9(1), 52.

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For research use only. Not intended for any clinical use.

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