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Mouse Anti-MYCBP Recombinant Antibody (CB276A) (CBMAB-CA276LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CB276A
Antibody Isotype
IgG
Application
ELISA, IHC

Basic Information

Immunogen
Recombinant Human MYCBP Protein
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
50% Glycerol
Preservative
0.03% Proclin 300
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
MYC Binding Protein
Introduction
The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]
Entrez Gene ID
26292
UniProt ID
Q99417
Alternative Names
MYC Binding Protein; C-Myc Binding Protein; Associate Of Myc-1; AMY-1; C-Myc-Binding Protein; Associate Of Myc 1; AMY1;
Function
May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.
Biological Process
Regulation of transcription, DNA-templated Source: UniProtKB
Spermatogenesis Source: UniProtKB
Cellular Location
Cytoplasm
Nucleus
Mitochondrion
Note: Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.
More Infomation

Panagopoulos, I., Andersen, K., Johannsdottir, I. M. R., Micci, F., & Heim, S. (2023). Novel MYCBP:: EHD2 and RUNX1:: ZNF780A fusion genes in T-cell acute lymphoblastic Leukemia. Cancer Genomics & Proteomics, 20(1), 51-63.

Alghasi, A., Saki, N., & Kaydani, G. A. (2023). Upregulation of the long noncoding RNA GJA9-MYCBP and PVT1 is a potential diagnostic biomarker for Acute Lymphoblastic Leukemia.

Wang, A., Zhang, T., Wei, W., Wang, H., Zhang, Z., Yang, W., ... & Dong, G. (2021). The long noncoding RNA LINC00665 facilitates c-Myc transcriptional activity via the miR-195-5p MYCBP axis to promote progression of lung adenocarcinoma. Frontiers in oncology, 11, 666551.

Ma, S., Wei, H., Wang, C., Han, J., Chen, X., & Li, Y. (2021). MiR-26b-5p inhibits cell proliferation and EMT by targeting MYCBP in triple-negative breast cancer. Cellular & molecular biology letters, 26(1), 1-12.

Qian, J., Garg, A., Li, F., Shen, Q., & Xiao, K. (2020). lncRNA LUNAR1 accelerates colorectal cancer progression by targeting the miR‑495‑3p/MYCBP axis. International Journal of Oncology, 57(5), 1157-1168.

Zhu, X. X., Li, J. H., Cai, J. P., Hou, X., Huang, C. S., Huang, X. T., ... & Yin, X. Y. (2019). EYA4 inhibits hepatocellular carcinoma by repressing MYCBP by dephosphorylating β‐catenin at Ser552. Cancer Science, 110(10), 3110-3121.

Li, C., Tan, F., Pei, Q., Zhou, Z., Zhou, Y., Zhang, L., ... & Pei, H. (2019). Non‐coding RNA MFI2‐AS1 promotes colorectal cancer cell proliferation, migration and invasion through miR‐574‐5p/MYCBP axis. Cell proliferation, 52(4), e12632.

Ma, D. (2019). Exosomal LINC00174 facilitates epithelial-mesenchymal transition in residual hepatocellular carcinoma after insufficient radiofrequency ablation by regulating c-JUN/MYCBP/c-Myc axis. Annals of Oncology, 30, ix53-ix54.

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For research use only. Not intended for any clinical use.

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