MYCBP
The protein encoded by this gene binds to the N-terminus of the oncogenic protein C-MYC, enhancing the ability of C-MYC to activate E box-dependent transcription. The encoded protein is normally found in the cytoplasm, but it translocates to the nucleus during S phase of the cell cycle and associates with C-MYC. This protein may be involved in spermatogenesis. This gene can be silenced by microRNA-22. Two transcript variants, one protein-coding and the other probably not protein-coding, have been found for this gene. [provided by RefSeq, Nov 2011]
Full Name
MYC Binding Protein
Function
May control the transcriptional activity of MYC. Stimulates the activation of E box-dependent transcription by MYC.
Biological Process
Regulation of transcription, DNA-templated Source: UniProtKB
Spermatogenesis Source: UniProtKB
Spermatogenesis Source: UniProtKB
Cellular Location
Cytoplasm
Nucleus
Mitochondrion
Note: Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.
Nucleus
Mitochondrion
Note: Translocates into the nucleus in the S phase of the cell cycle upon an increase of MYC expression. Found in the mitochondria when associated with AKAP1.
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Anti-MYCBP antibodies
+ Filters
Target: MYCBP
Sensitivity: 0.04 ng/mL
Detection Range: 0.1-40 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Target: MYCBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A1265
Application*: ELISA, IHC
Target: MYCBP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CB276A
Application*: ELISA, IHC
Target: MYCBP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1B12
Application*: WB, E
Target: MYCBP
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2E9
Application*: WB, E
Target: MYCBP
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 1D5D5
Application*: E, IH
Target: MYCBP
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-2894
Application*: E, WB, IH
Target: MYCBP
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-2893
Application*: E, WB
Target: MYCBP
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-2892
Application*: DB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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