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Mouse Anti-NCS1 Recombinant Antibody (CBXF-1506) (CBMAB-F2779-CQ)

This product is a mouse antibody that recognizes NCS1. The antibody CBXF-1506 can be used for immunoassay techniques such as: WB, ELISA.
See all NCS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXF-1506
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
Recombinant human NCS1 (1-190aa) purified from E. coli
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Neuronal Calcium Sensor 1
Introduction
This gene is a member of the neuronal calcium sensor gene family, which encode calcium-binding proteins expressed predominantly in neurons. The protein encoded by this gene regulates G protein-coupled receptor phosphorylation in a calcium-dependent manner and can substitute for calmodulin. The protein is associated with secretory granules and modulates synaptic transmission and synaptic plasticity. Multiple transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
23413
UniProt ID
P62166
Alternative Names
Neuronal Calcium Sensor 1; Frequenin-Like Ubiquitous Protein; Frequenin-Like Protein; Frequenin Homolog; FREQ; FLUP; Frequenin (Drosophila) Homolog; Frequenin Homolog (Drosophila); NCS-1;
Function
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin (By similarity).

Stimulates PI4KB kinase activity (By similarity).

Involved in long-term synaptic plasticity through its interaction with PICK1 (By similarity).

May also play a role in neuron differentiation through inhibition of the activity of N-type voltage-gated calcium channel (By similarity).
Biological Process
Regulation of neuron projection development Source: UniProtKB
Cellular Location
Golgi apparatus
Plasma membrane
Cell membrane
Cytoplasm
Other locations
postsynaptic density
perinuclear region
Membrane
Note: Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions.

Baksheeva, V. E., Zamyatnin Jr, A. A., & Zernii, E. Y. (2023). Neuronal Calcium Sensor-1: A Zinc/Redox-Dependent Protein of Nervous System Signaling Pathways. Molecular Biology, 57(6), 1097-1124.

Muñoz-Reyes, D., McClelland, L. J., Arroyo-Urea, S., Sánchez-Yepes, S., Sabín, J., Pérez-Suárez, S., ... & Sanchez-Barrena, M. J. (2023). The neuronal calcium sensor NCS-1 regulates the phosphorylation state and activity of the Gα chaperone and GEF Ric-8A. Elife, 12, e86151.

Fischer, T. T., Nguyen, L. D., & Ehrlich, B. E. (2021). Neuronal calcium sensor 1 (NCS1) dependent modulation of neuronal morphology and development. The FASEB Journal, 35(10), e21873.

Ng, E., Georgiou, J., Avila, A., Trought, K., Mun, H. S., Hodgson, M., ... & Wong, A. H. (2020). Mice lacking neuronal calcium sensor-1 show social and cognitive deficits. Behavioural Brain Research, 381, 112420.

Apasu, J. E., Schuette, D., LaRanger, R., Steinle, J. A., Nguyen, L. D., Grosshans, H. K., ... & Ehrlich, B. E. (2019). Neuronal calcium sensor 1 (NCS1) promotes motility and metastatic spread of breast cancer cells in vitro and in vivo. The FASEB Journal, 33(4), 4802.

Nakamura, T. Y., Nakao, S., & Wakabayashi, S. (2019). Emerging roles of neuronal Ca2+ sensor-1 in cardiac and neuronal tissues: A mini review. Frontiers in molecular neuroscience, 12, 56.

Catoni, C., Calì, T., & Brini, M. (2019). Calcium, dopamine and neuronal calcium sensor 1: their contribution to Parkinson’s disease. Frontiers in molecular neuroscience, 12, 55.

Bandura, J., & Feng, Z. P. (2019). Current understanding of the role of neuronal calcium sensor 1 in neurological disorders. Molecular Neurobiology, 56, 6080-6094.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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