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Mouse Anti-NOP56 Recombinant Antibody (CBWJN-0586) (CBMAB-N2942-WJ)

This product is a Mouse antibody that recognizes NOP56. The antibody CBWJN-0586 can be used for immunoassay techniques such as: WB, IHC, IF.
See all NOP56 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBWJN-0586
Antibody Isotype
IgG1
Application
WB, IHC, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
NOP56 ribonucleoprotein
Introduction
Nop56p is a yeast nucleolar protein that is part of a complex with the nucleolar proteins Nop58p and fibrillarin. Nop56p is required for assembly of the 60S ribosomal subunit and is involved in pre-rRNA processing. The protein encoded by this gene is similar in sequence to Nop56p and is also found in the nucleolus. Expansion of a GGCCTG repeat from 3-8 copies to 1500-2500 copies in an intron of this gene results in spinocerebellar ataxia 36. Multiple transcript variants encoding several different isoforms have been found for this gene, but the full-length nature of most of them has not been determined. [provided by RefSeq, Jul 2016]
Entrez Gene ID
10528
UniProt ID
O00567
Alternative Names
NOP56 Ribonucleoprotein; Nucleolar Protein 5A (56kDa With KKE/D Repeat); NOL5A; Nucleolar Protein 5A (56kD With KKE/D Repeat); NOP56 Ribonucleoprotein Homolog (Yeast); NOP56 Ribonucleoprotein Homolog;
Function
Involved in the early to middle stages of 60S ribosomal subunit biogenesis. Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such U3, U8 and U14 snoRNAs.
Biological Process
rRNA processingManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Nucleus, nucleolus
Cytoplasm
Nucleus, nucleoplasm
Involvement in disease
Spinocerebellar ataxia 36 (SCA36):
A form of spinocerebellar ataxia, a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA36 is characterized by complicated clinical features, with ataxia as the first symptom, followed by characteristic late-onset involvement of the motor neuron system. Ataxic symptoms, such as gait and truncal instability, ataxic dysarthria, and uncoordinated limbs, start in late forties to fifties. Characteristically, affected individuals exhibit tongue atrophy with fasciculation. Progression of motor neuron involvement is typically limited to the tongue and main proximal skeletal muscles in both upper and lower extremities.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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