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Mouse Anti-PCGF1 Recombinant Antibody (RNL-4) (CBMAB-P1040-YC)

Provided herein is a Mouse monoclonal antibody against Human Polycomb Group Ring Finger 1. The antibody can be used for immunoassay techniques, such as WB, IHC, IHC-P, IHC-Fr.
See all PCGF1 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
RNL-4
Antibody Isotype
IgG1
Application
WB, IHC, IHC-P, IHC-Fr

Basic Information

Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Polycomb Group Ring Finger 1
Introduction
PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development.
Entrez Gene ID
Human84759
Rat312480
UniProt ID
HumanQ9BSM1
RatQ6DLV9
Alternative Names
Polycomb Group Ring Finger 1; Nervous System Polycomb-1; RING Finger Protein 68; NSPC1; RNF68; Polycomb Group RING Finger Protein 1; 2010002K04Rik; RNF3A-2;
Function
Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332).
Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).
Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479).
Biological Process
Histone H2A monoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H2A-K119 monoubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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