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Mouse Anti-PCGF1 Recombinant Antibody (RNL-4) (CBMAB-P1040-YC)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
RNL-4
Antibody Isotype
IgG1
Application
WB, IHC, IHC-P, IHC-Fr

Basic Information

Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Polycomb Group Ring Finger 1
Introduction
PCGF1 is a mammalian homolog of the Drosophila polycomb group genes, which act as transcriptional repressors to regulate anterior-posterior patterning in early embryonic development.
Entrez Gene ID
Human84759
Rat312480
UniProt ID
HumanQ9BSM1
RatQ6DLV9
Alternative Names
Polycomb Group Ring Finger 1; Nervous System Polycomb-1; RING Finger Protein 68; NSPC1; RNF68; Polycomb Group RING Finger Protein 1; 2010002K04Rik; RNF3A-2;
Function
Component of the Polycomb group (PcG) multiprotein BCOR complex, a complex required to maintain the transcriptionally repressive state of some genes, such as BCL6 and the cyclin-dependent kinase inhibitor, CDKN1A. Transcriptional repressor that may be targeted to the DNA by BCL6; this transcription repressor activity may be related to PKC signaling pathway. Represses CDKN1A expression by binding to its promoter, and this repression is dependent on the retinoic acid response element (RARE element). Promotes cell cycle progression and enhances cell proliferation as well. May have a positive role in tumor cell growth by down-regulating CDKN1A. Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332).
Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).
Regulates the expression of DPPA4 and NANOG in the NT2 embryonic carcinoma cells (PubMed:26687479).
Biological Process
Histone H2A monoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H2A-K119 monoubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Nucleus
More Infomation

Yin, H., Wu, D., Qu, Q., Li, Z., & Zhao, L. (2024). Ubiquitin-specific peptidase 15 regulates the TFAP4/PCGF1 axis facilitating liver metastasis of colorectal cancer and cell stemness. Biochemical Pharmacology, 116319.

Putra, B. P., Ito, K., Cirillo, C., Sunardi, M., Koseki, H., Uesaka, T., & Enomoto, H. (2023). Pcgf1 gene disruption reveals primary involvement of epigenetic mechanism in neuronal subtype specification in the enteric nervous system. Development, Growth & Differentiation, 65(8), 461-469.

Zeng, Y., & Fan, R. (2022). PCGF1 is highly expressed in rectal adenocarcinoma and silencing PCGF1 inhibits proliferation of rectal adenocarcinoma cells in vitro. Nan Fang yi ke da xue xue bao= Journal of Southern Medical University, 42(9), 1296-1302.

Takano, J., Ito, S., Dong, Y., Sharif, J., Nakajima-Takagi, Y., Umeyama, T., ... & Ikawa, T. (2022). PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment. Nature communications, 13(1), 7159.

Xie, J., Qiao, L., Deng, G., Liang, N., Xing, L., & Zhang, J. (2022). PCGF1 is a prognostic biomarker and correlates with tumor immunity in gliomas. Annals of Translational Medicine, 10(4).

Sugishita, H., Kondo, T., Ito, S., Nakayama, M., Yakushiji-Kaminatsui, N., Kawakami, E., ... & Koseki, H. (2021). Variant PCGF1-PRC1 links PRC2 recruitment with differentiation-associated transcriptional inactivation at target genes. Nature Communications, 12(1), 5341.

Ji, G., Zhou, W., Du, J., Zhou, J., Wu, D., Zhao, M., ... & Hao, A. (2021). PCGF1 promotes epigenetic activation of stemness markers and colorectal cancer stem cell enrichment. Cell Death & Disease, 12(7), 633.

Li, X., Ji, G., Zhou, J., Du, J., Li, X., Shi, W., ... & Hao, A. (2021). Pcgf1 regulates early neural tube development through histone methylation in zebrafish. Frontiers in cell and developmental biology, 8, 581636.

Yan, R., Cui, F., Dong, L., Liu, Y., Chen, X., & Fan, R. (2020). Repression of PCGF1 decreases the proliferation of glioblastoma cells in association with inactivation of c-Myc signaling pathway. OncoTargets and therapy, 253-261.

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For research use only. Not intended for any clinical use.

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