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Mouse Anti-PCGF5 Recombinant Antibody (3C10) (CBMAB-P1044-YC)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
3C10
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, WB

Basic Information

Immunogen
PCGF5 (NP_115749.2, 51-148 aa) partial recombinant protein with GST tag. Immunogen sequence: NDCPRCGNQV HETNPLEMLR LDNTLEEIIF KLVPGLREQE LERESEFWKK NKPQENGQDD TSKADKPKVD EEGDENEDDK DYHRSDPQIA ICLDCLRN
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 51-148

Target

Full Name
polycomb group ring finger 5
Introduction
PCGF5 has ubiquitous expression in thyroid (RPKM 14.7), adrenal (RPKM 12.4) and 25 other tissues.
Entrez Gene ID
84333
UniProt ID
Q86SE9
Alternative Names
Polycomb Group Ring Finger 5; Ring Finger Protein (C3HC4 Type) 159; RING Finger Protein 159; RNF159; Polycomb Group RING Finger Protein 5;
Function
Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332).
Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).
Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).
Biological Process
Histone H2A-K119 monoubiquitinationISS:UniProtKB
Inactivation of X chromosome by genomic imprintingISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Nucleus, nucleoplasm
Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome.
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For research use only. Not intended for any clinical use.

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