PCGF5

PCGF5 has ubiquitous expression in thyroid (RPKM 14.7), adrenal (RPKM 12.4) and 25 other tissues.

Full Name

polycomb group ring finger 5

Function

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332).
Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332).
Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).

Biological Process

Histone H2A-K119 monoubiquitinationISS:UniProtKB
Inactivation of X chromosome by genomic imprintingISS:UniProtKB
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:MGI
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Nucleus
Nucleus, nucleoplasm
Recruited by the non-coding RNA Xist to specific nuclear foci that probably correspond to the inactivated X chromosome.