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Mouse Anti-CECR2 Recombinant Antibody (CBWJC-2465) (CBMAB-C3533WJ)

This product is a Mouse antibody that recognizes CECR2. This antibody CBWJC-2465 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all CECR2 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBWJC-2465
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
CECR2, Histone Acetyl-Lysine Reader
Introduction
This gene encodes a bromodomain-containing protein that is involved in chromatin remodeling, and may additionally play a role in DNA damage response. The encoded protein functions as part of an ATP-dependent complex that is involved in neurulation. This gene is a candidate gene for Cat Eye Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Entrez Gene ID
Human27443
Mouse330409
Rat500308
UniProt ID
HumanQ9BXF3
MouseE9Q2Z1
RatF1LYI0
Alternative Names
CECR2, Histone Acetyl-Lysine Reader; Cat Eye Syndrome Chromosome Region, Candidate 2; KIAA1740;
Function
Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI-type complex (PubMed:15640247, PubMed:26365797, PubMed:22464331).
It thereby plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity).
In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797, PubMed:22464331).
May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (PubMed:11827465).
Biological Process
Apoptotic DNA fragmentation Source: HGNC-UCL
ATP-dependent chromatin remodeling Source: MGI
Cochlea development Source: Ensembl
Cytoskeleton-dependent cytokinesis Source: UniProtKB
Cytoskeleton organization Source: UniProtKB
Execution phase of apoptosis Source: BHF-UCL
Inner ear receptor cell stereocilium organization Source: Ensembl
Neural fold formation Source: Ensembl
Neural tube closure Source: Ensembl
Single fertilization Source: GO_Central
Vesicle-mediated transport Source: UniProtKB
Cellular Location
CERF complex; Nucleus; Euchromatin
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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