CECR2

This gene encodes a bromodomain-containing protein that is involved in chromatin remodeling, and may additionally play a role in DNA damage response. The encoded protein functions as part of an ATP-dependent complex that is involved in neurulation. This gene is a candidate gene for Cat Eye Syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]

Full Name

CECR2, Histone Acetyl-Lysine Reader

Function

Chromatin reader component of histone-modifying complexes, such as the CERF (CECR2-containing-remodeling factor) complex and ISWI-type complex (PubMed:15640247, PubMed:26365797, PubMed:22464331).
It thereby plays a role in various processes during development: required during embryogenesis for neural tube closure and inner ear development. In adults, required for spermatogenesis, via the formation of ISWI-type chromatin complexes (By similarity).
In histone-modifying complexes, CECR2 recognizes and binds acylated histones: binds histones that are acetylated and/or butyrylated (PubMed:26365797, PubMed:22464331).
May also be involved through its interaction with LRPPRC in the integration of cytoskeletal network with vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis (PubMed:11827465).

Biological Process

Apoptotic DNA fragmentation Source: HGNC-UCL
ATP-dependent chromatin remodeling Source: MGI
Cochlea development Source: Ensembl
Cytoskeleton-dependent cytokinesis Source: UniProtKB
Cytoskeleton organization Source: UniProtKB
Execution phase of apoptosis Source: BHF-UCL
Inner ear receptor cell stereocilium organization Source: Ensembl
Neural fold formation Source: Ensembl
Neural tube closure Source: Ensembl
Single fertilization Source: GO_Central
Vesicle-mediated transport Source: UniProtKB

Cellular Location

CERF complex; Nucleus; Euchromatin