Mouse Anti-CD1C Recombinant Antibody (L161) (CBMAB-C2173-CQ)

Name: Mouse Anti-CD1C Recombinant Antibody (L161)
SKU: CBMAB-C2173-CQ
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-CD1C Recombinant Antibody (L161) (CBMAB-C2173-CQ) in FC

Presence of DN4.99 TCR-T cells in the bone marrow of NALM-6 CD1c bearing mice, determined by flow cytometry 4 days after their adoptive transfer. DN4.99 TCR-T cells were identified as mouse (m)TCRb+ cells in the human (h)CD45+ mouse (m)CD45- cells. ...View More

Consonni, M., Garavaglia, C., Grilli, A., de Lalla, C., Mancino, A., Mori, L., ... & Casorati, G. (2021). Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia. Nature Communications, 12(1), 4844. Distributed under Open Access license CC BY 4.0, without modification.

Mouse Anti-CD1C Recombinant Antibody (L161) (CBMAB-C2173-CQ) in FC

Flow cytometry detection of CD1c expression (black histograms) on ex vivo B-Acute Lymphoblastic Leukemia (B-ALL) and Acute Myeloid Leukemia (AML) blasts labeled with anti-human CD1c monoclonal antibody (mAb). White histograms represent labeling with isotype-matched control mAb. Relative Fluorescence Intensity (RFI) was calculated as the ratio between the intensity of labeling of sample and control. ...View More

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

L161

Application

FC, IP, IF

Immunogen

Thymus cells.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
IP	1-2 µg per 100-500 µg of total protein (1 ml of cell lysate)
IF(ICC)	1:50-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% gelatin

Preservative

< 0.1% sodium azide

Concentration

0.2 mg/ml

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

CD1c molecule

Introduction

CD1C (CD1c Molecule) is a Protein Coding gene. Diseases associated with CD1C include Mycobacterium Malmoense and Foramen Magnum Meningioma. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include beta-2-microglobulin binding and lipopeptide binding. An important paralog of this gene is CD1B.

Entrez Gene ID

911

UniProt ID

P29017

Function

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Biological Process

Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
T cell activation involved in immune response Source: UniProtKB

Cellular Location

Endosome membrane; Cell membrane; Lysosome. Subject to intracellular trafficking between the cell membrane and endosomes.

Topology

Extracellular: 18-302
Helical: 303-323
Cytoplasmic: 324-333

Reijneveld, J. F., Marino, L., Cao, T. P., Cheng, T. Y., Dam, D., Shahine, A., ... & Van Rhijn, I. (2021). Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells. Journal of Biological Chemistry, 297(4).

Wun, K. S., Reijneveld, J. F., Cheng, T. Y., Ladell, K., Uldrich, A. P., Le Nours, J., ... & Rossjohn, J. (2018). T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids. Nature immunology, 19(4), 397-406.

Guo, T., Koo, M. Y., Kagoya, Y., Anczurowski, M., Wang, C. H., Saso, K., ... & Hirano, N. (2018). A subset of human autoreactive CD1c-restricted T cells preferentially expresses TRBV4-1+ TCRs. The Journal of Immunology, 200(2), 500-511.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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