Mouse Anti-CD1C Recombinant Antibody (CBT4317) (V2LY-0625-LY901)

Name: Mouse Anti-CD1C Recombinant Antibody (CBT4317)
SKU: V2LY-0625-LY901
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-CD1C Recombinant Antibody (CBT4317) (V2LY-0625-LY901) in ELISA

Mouse Anti-CD1C Recombinant Antibody (CBT4317) (V2LY-0625-LY901) in WB

Mouse Anti-CD1C Recombinant Antibody (CBT4317) (V2LY-0625-LY901) in FC

Mouse Anti-CD1C Recombinant Antibody (CBT4317) (V2LY-0625-LY901) in IHC

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT4317

Application

IHC, FC

Immunogen

Purified recombinant fragment of human CD1C (AA: extra 18-302) expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2b

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
IHC-P	1:200-1:1,000
FC	1:200-1:400
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

CD1c molecule

Entrez Gene ID

911

UniProt ID

P29017

Function

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Biological Process

Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
T cell activation involved in immune response Source: UniProtKB

Cellular Location

Endosome membrane; Cell membrane; Lysosome. Subject to intracellular trafficking between the cell membrane and endosomes.

Topology

Extracellular: 18-302
Helical: 303-323
Cytoplasmic: 324-333

Consonni, M., Garavaglia, C., Grilli, A., de Lalla, C., Mancino, A., Mori, L., ... & Casorati, G. (2021). Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia. Nature Communications, 12(1), 1-14.

Reijneveld, J. F., Marino, L., Cao, T. P., Cheng, T. Y., Dam, D., Shahine, A., ... & Van Rhijn, I. (2021). Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells. Journal of Biological Chemistry, 297(4).

Wun, K. S., Reijneveld, J. F., Cheng, T. Y., Ladell, K., Uldrich, A. P., Le Nours, J., ... & Rossjohn, J. (2018). T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids. Nature immunology, 19(4), 397-406.

Guo, T., Koo, M. Y., Kagoya, Y., Anczurowski, M., Wang, C. H., Saso, K., ... & Hirano, N. (2018). A subset of human autoreactive CD1c-restricted T cells preferentially expresses TRBV4-1+ TCRs. The Journal of Immunology, 200(2), 500-511.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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