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Mouse Anti-CD1C Recombinant Antibody (4B11) (CBMAB-C6633-LY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
4B11
Antibody Isotype
IgG2a, κ
Application
ELISA

Basic Information

Immunogen
CD1C (77 a.a. ~ 185 a.a) partial recombinant protein with GST tag.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal Antibody
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
CD1c molecule
Introduction
CD1C (CD1c Molecule) is a Protein Coding gene. Diseases associated with CD1C include Mycobacterium Malmoense and Foramen Magnum Meningioma. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include beta-2-microglobulin binding and lipopeptide binding.
An important paralog of this gene is CD1B.
Entrez Gene ID
911
UniProt ID
P29017
Function
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
T cell activation involved in immune response Source: UniProtKB
Cellular Location
Endosome membrane; Cell membrane; Lysosome. Subject to intracellular trafficking between the cell membrane and endosomes.
Topology
Extracellular: 18-302
Helical: 303-323
Cytoplasmic: 324-333
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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