Mouse Anti-CD1C Recombinant Antibody (4B11) (CBMAB-C6633-LY)

Name: Mouse Anti-CD1C Recombinant Antibody (4B11)
SKU: CBMAB-C6633-LY
Rating: 5 (1 reviews)

See all CD1C antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4B11

Application

ELISA

Immunogen

CD1C (77 a.a. ~ 185 a.a) partial recombinant protein with GST tag.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a, κ

Clonality

Monoclonal Antibody

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

None

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

CD1c molecule

Introduction

CD1C (CD1c Molecule) is a Protein Coding gene. Diseases associated with CD1C include Mycobacterium Malmoense and Foramen Magnum Meningioma. Among its related pathways are Hematopoietic Stem Cell Differentiation Pathways and Lineage-specific Markers and Innate Immune System. Gene Ontology (GO) annotations related to this gene include beta-2-microglobulin binding and lipopeptide binding.
An important paralog of this gene is CD1B.

Entrez Gene ID

911

UniProt ID

P29017

Function

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

Biological Process

Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
T cell activation involved in immune response Source: UniProtKB

Cellular Location

Endosome membrane; Cell membrane; Lysosome. Subject to intracellular trafficking between the cell membrane and endosomes.

Topology

Extracellular: 18-302
Helical: 303-323
Cytoplasmic: 324-333

Consonni, M., Garavaglia, C., Grilli, A., de Lalla, C., Mancino, A., Mori, L., ... & Casorati, G. (2021). Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia. Nature Communications, 12(1), 1-14.

Reijneveld, J. F., Marino, L., Cao, T. P., Cheng, T. Y., Dam, D., Shahine, A., ... & Van Rhijn, I. (2021). Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells. Journal of Biological Chemistry, 297(4).

Wun, K. S., Reijneveld, J. F., Cheng, T. Y., Ladell, K., Uldrich, A. P., Le Nours, J., ... & Rossjohn, J. (2018). T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids. Nature immunology, 19(4), 397-406.

Guo, T., Koo, M. Y., Kagoya, Y., Anczurowski, M., Wang, C. H., Saso, K., ... & Hirano, N. (2018). A subset of human autoreactive CD1c-restricted T cells preferentially expresses TRBV4-1+ TCRs. The Journal of Immunology, 200(2), 500-511.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-CD1C Recombinant Antibody (4B11)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Related Products

Rabbit Anti-CD1C Recombinant Antibody (CBXC-1969) (CAT#: CBMAB-C4800-CQ)

Mouse Anti-CD1C Recombinant Antibody (CBXC-0183) (CAT#: CBMAB-C4796-CQ)

Mouse Anti-CD1C Recombinant Antibody (CBXC-2225) (CAT#: CBMAB-C4797-CQ)

Mouse Anti-CD1C Recombinant Antibody (M241) (CAT#: CBMAB-C0843-CQ)

Mouse Anti-CD1C Recombinant Antibody (AD5-8E7) (CAT#: CBMAB-C1713-CQ)

Mouse Anti-CD1C Recombinant Antibody (CBT4317) (CAT#: V2LY-0625-LY901)

Human Anti-CD1C Recombinant Antibody (CBXC-0912) (CAT#: CBMAB-C2027-CQ)

Mouse Anti-CD1C Recombinant Antibody (CBXC-2608) (CAT#: CBMAB-C4798-CQ)

Mouse Anti-CD1C Recombinant Antibody (CBT2915) (CAT#: V2LY-0625-LY900)

Mouse Anti-CD1C Recombinant Antibody (L161) (CAT#: CBMAB-C2173-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry