Human CD1C ELISA Kit (V2LY-0626-LY5309)

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Tested Data
Datasheet
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Basic Information

Sensitivity
0.096 ng/mL
Detection Range
0.2-70 ng/mL
Sample Type
Serum, Plasma, cell culture supernates
Specificity
Human
Assay Type
Sandwich
Reactivity
Human
Assay Time
1.5 h
Molecule Mass
37.7 kDa
Components
  • Pre-coated ELISA plate: 12 wells * 8 detachable strips
  • Standard solution: 0.5ml x1
  • Standard diluent: 3ml x1
  • Streptavidin-HRP: 6ml x1
  • Stop solution: 6ml x1
  • Substrate solution A: 6ml x1
  • Substrate solution B: 6ml x1
  • Wash buffer concentrate (25x): 20ml x1
  • Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 2-8°C
More Infomation

Target

Full Name
CD1c molecule
Function
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
T cell activation involved in immune response Source: UniProtKB
Cellular Location
Endosome membrane; Cell membrane; Lysosome. Subject to intracellular trafficking between the cell membrane and endosomes.
Topology
Extracellular: 18-302
Helical: 303-323
Cytoplasmic: 324-333

Consonni, M., Garavaglia, C., Grilli, A., de Lalla, C., Mancino, A., Mori, L., ... & Casorati, G. (2021). Human T cells engineered with a leukemia lipid-specific TCR enables donor-unrestricted recognition of CD1c-expressing leukemia. Nature Communications, 12(1), 1-14.

Reijneveld, J. F., Marino, L., Cao, T. P., Cheng, T. Y., Dam, D., Shahine, A., ... & Van Rhijn, I. (2021). Rational design of a hydrolysis-resistant mycobacterial phosphoglycolipid antigen presented by CD1c to T cells. Journal of Biological Chemistry, 297(4).

Wun, K. S., Reijneveld, J. F., Cheng, T. Y., Ladell, K., Uldrich, A. P., Le Nours, J., ... & Rossjohn, J. (2018). T cell autoreactivity directed toward CD1c itself rather than toward carried self lipids. Nature immunology, 19(4), 397-406.

Guo, T., Koo, M. Y., Kagoya, Y., Anczurowski, M., Wang, C. H., Saso, K., ... & Hirano, N. (2018). A subset of human autoreactive CD1c-restricted T cells preferentially expresses TRBV4-1+ TCRs. The Journal of Immunology, 200(2), 500-511.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rhesus Recombinant CD1C & B2M protein, Hetero Dimer , His Tag (CAT#: V2LY-0526-LY9667)

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Isotype control

For research use only. Not intended for any clinical use.

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