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CD1C

This gene encodes a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail. Alternatively spliced transcript variants of this gene have been observed, but their full-length nature is not known. [provided by RefSeq]
Full Name
CD1c molecule
Function
Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.
Biological Process
Adaptive immune response Source: UniProtKB-KW
Antigen processing and presentation, endogenous lipid antigen via MHC class Ib Source: GO_Central
Antigen processing and presentation, exogenous lipid antigen via MHC class Ib Source: GO_Central
Positive regulation of T cell mediated cytotoxicity Source: GO_Central
Regulation of immune response Source: Reactome
T cell activation involved in immune response Source: UniProtKB
Cellular Location
Endosome membrane; Cell membrane; Lysosome. Subject to intracellular trafficking between the cell membrane and endosomes.
Topology
Extracellular: 18-302
Helical: 303-323
Cytoplasmic: 324-333
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Anti-CD1C antibodies

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Mouse Anti-CD1C Recombinant Antibody (L161) (CBMAB-C2173-CQ)

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Target: CD1C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: L161
Application*: F, IP, IF
Datasheet SDS

Mouse Anti-CD1C Recombinant Antibody (AD5-8E7) (CBMAB-C1713-CQ)

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Target: CD1C
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: AD5-8E7
Application*: F, IF, IH
Datasheet SDS

Mouse Anti-CD1C Recombinant Antibody (CBT4317) (V2LY-0625-LY901)

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Target: CD1C
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT4317
Application*: IH, F
Datasheet SDS

Mouse Anti-CD1C Recombinant Antibody (CBT2915) (V2LY-0625-LY900)

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Target: CD1C
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT2915
Application*: IH, F
Datasheet SDS

Rabbit Anti-CD1C Recombinant Antibody (CBXC-1969) (CBMAB-C4800-CQ)

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Target: CD1C
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBXC-1969
Application*: WB
Datasheet SDS

Mouse Anti-CD1C Recombinant Antibody (CBXC-2608) (CBMAB-C4798-CQ)

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Target: CD1C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-2608
Application*: IP
Datasheet SDS

Mouse Anti-CD1C Recombinant Antibody (CBXC-2225) (CBMAB-C4797-CQ)

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Target: CD1C
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXC-2225
Application*: E
Datasheet SDS

Mouse Anti-CD1C Recombinant Antibody (CBXC-0183) (CBMAB-C4796-CQ)

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Target: CD1C
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXC-0183
Application*: WB, IP, IF, E
Datasheet SDS

Human Anti-CD1C Recombinant Antibody (CBXC-0912) (CBMAB-C2027-CQ)

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Target: CD1C
Host: Human
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXC-0912
Application*: F, IF, IH
Datasheet SDS

Mouse Anti-CD1C Recombinant Antibody (M241) (CBMAB-C0843-CQ)

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Target: CD1C
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: M241
Application*: IH, IP
Datasheet SDS

Mouse Anti-CD1C Recombinant Antibody (4B11) (CBMAB-C6633-LY)

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Target: CD1C
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4B11
Application*: E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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