Rabbit Anti-CCN1 Recombinant Antibody (CBWJC-3580) (CBMAB-C4816WJ)

CCN1

CYR61 (Cysteine Rich Angiogenic Inducer 61) is a Protein Coding gene. Diseases associated with CYR61 include Arthropathy, Progressive Pseudorheumatoid, Of Childhood and Epispadias. Among its related pathways are RhoA signaling pathway and Hypertrophy Model. Gene Ontology (GO) annotations related to this gene include heparin binding and extracellular matrix binding. An important paralog of this gene is CTGF.

Cysteine Rich Angiogenic Inducer 61; Insulin-Like Growth Factor-Binding Protein 10; IGF-Binding Protein 10; CCN Family Member 1; IGFBP-10; IGFBP10; IBP-10; CCN1;

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Apoptotic process involved in heart morphogenesis Source: Ensembl
Atrial septum morphogenesis Source: Ensembl
Atrioventricular valve morphogenesis Source: Ensembl
Cell adhesion Source: GO_Central
Cellular protein metabolic process Source: Reactome
Chemotaxis Source: UniProtKB-KW
Chondroblast differentiation Source: Ensembl
Chorio-allantoic fusion Source: Ensembl
Extracellular matrix organization Source: Ensembl
Intussusceptive angiogenesis Source: Ensembl
Labyrinthine layer blood vessel development Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of cell death Source: GO_Central
Osteoblast differentiation Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of BMP signaling pathway Source: BHF-UCL
Positive regulation of bone mineralization Source: BHF-UCL
Positive regulation of cartilage development Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of cell-substrate adhesion Source: Ensembl
Positive regulation of ceramide biosynthetic process Source: Ensembl
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Positive regulation of osteoblast differentiation Source: BHF-UCL
Positive regulation of osteoblast proliferation Source: BHF-UCL
Positive regulation of phospholipase activity Source: Ensembl
Positive regulation of protein kinase activity Source: BHF-UCL
Positive regulation of protein phosphorylation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Post-translational protein modification Source: Reactome
Reactive oxygen species metabolic process Source: Ensembl
Regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Signal transduction Source: GO_Central
Ventricular septum development Source: Ensembl
Wound healing, spreading of cells Source: BHF-UCL

Secreted