CCN1

Full Name

CCN1

Function

Promotes cell proliferation, chemotaxis, angiogenesis and cell adhesion. Appears to play a role in wound healing by up-regulating, in skin fibroblasts, the expression of a number of genes involved in angiogenesis, inflammation and matrix remodeling including VEGA-A, VEGA-C, MMP1, MMP3, TIMP1, uPA, PAI-1 and integrins alpha-3 and alpha-5. CCN1-mediated gene regulation is dependent on heparin-binding. Down-regulates the expression of alpha-1 and alpha-2 subunits of collagen type-1. Promotes cell adhesion and adhesive signaling through integrin alpha-6/beta-1, cell migration through integrin alpha-v/beta-5 and cell proliferation through integrin alpha-v/beta-3.

Biological Process

Apoptotic process involved in heart morphogenesis Source: Ensembl
Atrial septum morphogenesis Source: Ensembl
Atrioventricular valve morphogenesis Source: Ensembl
Cell adhesion Source: GO_Central
Cellular protein metabolic process Source: Reactome
Chemotaxis Source: UniProtKB-KW
Chondroblast differentiation Source: Ensembl
Chorio-allantoic fusion Source: Ensembl
Extracellular matrix organization Source: Ensembl
Intussusceptive angiogenesis Source: Ensembl
Labyrinthine layer blood vessel development Source: Ensembl
Negative regulation of apoptotic process Source: Ensembl
Negative regulation of cell death Source: GO_Central
Osteoblast differentiation Source: Ensembl
Positive regulation of apoptotic process Source: Ensembl
Positive regulation of BMP signaling pathway Source: BHF-UCL
Positive regulation of bone mineralization Source: BHF-UCL
Positive regulation of cartilage development Source: Ensembl
Positive regulation of cell migration Source: BHF-UCL
Positive regulation of cell-substrate adhesion Source: Ensembl
Positive regulation of ceramide biosynthetic process Source: Ensembl
Positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: Ensembl
Positive regulation of osteoblast differentiation Source: BHF-UCL
Positive regulation of osteoblast proliferation Source: BHF-UCL
Positive regulation of phospholipase activity Source: Ensembl
Positive regulation of protein kinase activity Source: BHF-UCL
Positive regulation of protein phosphorylation Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Post-translational protein modification Source: Reactome
Reactive oxygen species metabolic process Source: Ensembl
Regulation of ERK1 and ERK2 cascade Source: BHF-UCL
Signal transduction Source: GO_Central
Ventricular septum development Source: Ensembl
Wound healing, spreading of cells Source: BHF-UCL

Cellular Location

Secreted