Mouse Anti-APOH Recombinant Antibody (4D9A4) (CBMAB-A3249-YC)

Name: Mouse Anti-APOH Recombinant Antibody (4D9A4)
SKU: CBMAB-A3249-YC
Rating: 5 (1 reviews)

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Published Data

Mouse Anti-APOH Recombinant Antibody (4D9A4) in WB

A: Western blotting of plasma β2GPI of the family members; B: Western blotting analysis of recombinant β2GPI expressed in HEK-293T cells and culture media. ...View More

Zhang, X. P., Zeng, W., Liu, H., Tang, L., Wang, Q. Y., Cheng, Z. P., ... & Hu, Y. (2018). Thrombophilia caused by Beta2-Glycoprotein I deficiency: in vitro study of a rare mutation in APOH gene. Current Medical Science, 38(2), 379-385.

Mouse Anti-APOH Recombinant Antibody (4D9A4) in WB

Western blotting of plasma β2GPI. Plasma β-actin was used as an internal control. ...View More

Tang, L., Zeng, W., Lu, X., Wang, Q. Y., Liu, H., Cheng, Z. P., ... & Hu, Y. (2014). Identification of APOH polymorphisms as common genetic risk factors for venous thrombosis in the Chinese population. Journal of Thrombosis and Haemostasis, 12(10), 1616-1625.

Datasheet

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

4D9A4

Application

IHC, WB

Immunogen

Apolipoprotein H Fusion Protein (20-345 aa).

Host Species

Mouse

Specificity

Human, Mouse, Pig, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Application	Note
WB	1:1,000-1:8,000
IHC-P	1:100-1:800

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, pH 7.3, 50% glycerol

Preservative

0.02% sodium azide

Concentration

Batch dependent

Storage

Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Apolipoprotein H

Introduction

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antipho

Entrez Gene ID

Human	350
Mouse	11818
Rat	287774
Pig	100522100

UniProt ID

Human	P02749
Mouse	Q01339
Rat	P26644
Pig	A0A286ZFW3

Alternative Names

Apolipoprotein H; Apolipoprotein H (Beta-2-Glycoprotein I); Activated Protein C-Binding Protein; Anticardiolipin Cofactor; Beta-2-Glycoprotein I; APC Inhibitor; Beta(2)GPI;

Function

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Biological Process

Blood coagulation, intrinsic pathway Source: BHF-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of blood coagulation Source: BHF-UCL
Negative regulation of endothelial cell migration Source: BHF-UCL
Negative regulation of endothelial cell proliferation Source: BHF-UCL
Negative regulation of fibrinolysis Source: BHF-UCL
Negative regulation of myeloid cell apoptotic process Source: BHF-UCL
Negative regulation of smooth muscle cell apoptotic process Source: BHF-UCL
Plasminogen activation Source: BHF-UCL
Platelet degranulation Source: Reactome
Positive regulation of blood coagulation Source: BHF-UCL
Positive regulation of lipoprotein lipase activity Source: BHF-UCL
Regulation of fibrinolysis Source: BHF-UCL
Triglyceride metabolic process Source: BHF-UCL
Triglyceride transport Source: BHF-UCL

Cellular Location

Secreted

PTM

N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele.

Liu, Y., Maiers, J. L., Rui, Y., Jiang, X., Guleng, B., & Ren, J. (2021). Apolipoprotein H drives hepatitis B surface antigen retention and endoplasmic reticulum stress during hepatitis B virus infection. The International Journal of Biochemistry & Cell Biology, 131, 105906.

Liu, Y., Maiers, J. L., Wu, Y., Fu, B., Guo, X., Huang, X., ... & Ren, J. (2021). 713d Downregulation of Apolipoprotein H Induce Hepatocyte Steatosis to Promote Gut Microbiota Dysbiosis in Chronic Hepatitis B Infection. Gastroenterology, 161(2), e26.

Tan, Y., Bian, Y., Song, Y., Zhang, Q., & Wan, X. (2021). Exosome-Contained APOH Associated With Antiphospholipid Syndrome. Frontiers in Immunology, 12, 1237.

Wajda, A., Sowińska, A., Haładyj, E., Stypińska, B., Nałęcz-Janik, J., Jagodziński, P. P., ... & Paradowska-Gorycka, A. (2020). Tissue factor and human apolipoprotein H genetic variants and pro-inflammatory cytokines in systemic lupus erythematosus patients. Clinical and Experimental Rheumatology.

Khatri, S., Mellins, E. D., Torok, K. S., Bukhari, S. A., & Astakhova, K. (2020). Combined assay for detecting autoantibodies to nucleic acids and apolipoprotein H in patients with systemic lupus erythematosus. In Nucleic Acid Detection and Structural Investigations (pp. 57-71). Humana, New York, NY.

Abi Jomaa, R. (2020). Effects of Apolipoprotein H and STAT3 on Cell Clustering of Glioblastoma Multiforme Sub-Clones (Doctoral dissertation).

Zhang, X. P., Zeng, W., Liu, H., Tang, L., Wang, Q. Y., Cheng, Z. P., ... & Hu, Y. (2018). Thrombophilia Caused by Beta2-Glycoprotein I Deficiency: In Vitro Study of a Rare Mutation in APOH Gene. Current medical science, 38(2), 379-385.

e Cunha, C. S., Nyboer, B., Heiss, K., Sanches-Vaz, M., Fontinha, D., Wiedtke, E., ... & Mueller, A. K. (2017). Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development. Proceedings of the National Academy of Sciences, 114(7), E1138-E1147.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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