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APOH

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]
Full Name
Apolipoprotein H
Function
Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
Biological Process
Blood coagulation, intrinsic pathway Source: BHF-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of blood coagulation Source: BHF-UCL
Negative regulation of endothelial cell migration Source: BHF-UCL
Negative regulation of endothelial cell proliferation Source: BHF-UCL
Negative regulation of fibrinolysis Source: BHF-UCL
Negative regulation of myeloid cell apoptotic process Source: BHF-UCL
Negative regulation of smooth muscle cell apoptotic process Source: BHF-UCL
Plasminogen activation Source: BHF-UCL
Platelet degranulation Source: Reactome
Positive regulation of blood coagulation Source: BHF-UCL
Positive regulation of lipoprotein lipase activity Source: BHF-UCL
Regulation of fibrinolysis Source: BHF-UCL
Triglyceride metabolic process Source: BHF-UCL
Triglyceride transport Source: BHF-UCL
Cellular Location
Secreted
PTM
N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele.
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Anti-APOH antibodies

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Mouse Anti-APOH Recombinant Antibody (4D9A4) (CBMAB-A3249-YC)

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Target: APOH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Pig, Rat
Clone: 4D9A4
Application*: IH, WB
Datasheet SDS

Mouse Anti-APOH Recombinant Antibody (C2) (CBMAB-A3245-YC)

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Target: APOH
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: C2
Application*: E, IF, WB, IP
Datasheet SDS

Mouse Anti-APOH Recombinant Antibody (CBYC-A701) (CBMAB-A3255-YC)

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Target: APOH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-A701
Application*: E
Datasheet SDS

Mouse Anti-APOH Recombinant Antibody (CBYC-A700) (CBMAB-A3254-YC)

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Target: APOH
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBYC-A700
Application*: E, WB, IP
Datasheet SDS

Rabbit Anti-APOH Recombinant Antibody (CBYC-A699) (CBMAB-A3253-YC)

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Target: APOH
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-A699
Application*: E, P
Datasheet SDS

Mouse Anti-APOH Recombinant Antibody (H219) (CBMAB-A3251-YC)

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Target: APOH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: H219
Application*: E, WB
Datasheet SDS

Mouse Anti-APOH Recombinant Antibody (A3248) (CBMAB-A3248-YC)

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Target: APOH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: A3248
Application*: E, FC, IC, IF, WB
Datasheet SDS

Mouse Anti-APOH Recombinant Antibody (3F10) (CBMAB-A3246-YC)

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Target: APOH
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: 3F10
Application*: E, WB
Datasheet SDS

Mouse Anti-APOH Recombinant Antibody (1D2) (CBMAB-A3244-YC)

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Target: APOH
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1D2
Application*: E, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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