APOH

Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome, but it does not seem to be required for the reactivity of antiphospholipid autoantibodies associated with infections. [provided by RefSeq, Jul 2008]

Apolipoprotein H

Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.

Blood coagulation, intrinsic pathway Source: BHF-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of blood coagulation Source: BHF-UCL
Negative regulation of endothelial cell migration Source: BHF-UCL
Negative regulation of endothelial cell proliferation Source: BHF-UCL
Negative regulation of fibrinolysis Source: BHF-UCL
Negative regulation of myeloid cell apoptotic process Source: BHF-UCL
Negative regulation of smooth muscle cell apoptotic process Source: BHF-UCL
Plasminogen activation Source: BHF-UCL
Platelet degranulation Source: Reactome
Positive regulation of blood coagulation Source: BHF-UCL
Positive regulation of lipoprotein lipase activity Source: BHF-UCL
Regulation of fibrinolysis Source: BHF-UCL
Triglyceride metabolic process Source: BHF-UCL
Triglyceride transport Source: BHF-UCL

Secreted

N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele.