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Rabbit Anti-APOH Recombinant Antibody (CBYC-A699) (CBMAB-A3253-YC)

Provided herein is a Rabbit monoclonal antibody against Human Apolipoprotein H. The antibody can be used for immunoassay techniques, such as ICC, IF, IP, WB.
See all APOH antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
CBYC-A699
Antibody Isotype
IgG
Application
ELISA, IHC-P

Basic Information

Immunogen
Recombinant Human APOH protein.
Host Species
Rabbit
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.
ApplicationNote
ELISA1:5,000-1:10,000
IHC-P1:100-1:500

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
None
Concentration
Batch dependent
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Apolipoprotein H
Introduction
Apolipoprotein H has been implicated in a variety of physiologic pathways including lipoprotein metabolism, coagulation, and the production of antiphospholipid autoantibodies. APOH may be a required cofactor for anionic phospholipid binding by the antipho
Entrez Gene ID
Human350
Rat287774
UniProt ID
HumanP02749
RatP26644
Alternative Names
Apolipoprotein H; Apolipoprotein H (Beta-2-Glycoprotein I); Activated Protein C-Binding Protein; Anticardiolipin Cofactor; Beta-2-Glycoprotein I; APC Inhibitor; Beta(2)GPI;
Function
Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.
Biological Process
Blood coagulation, intrinsic pathway Source: BHF-UCL
Negative regulation of angiogenesis Source: BHF-UCL
Negative regulation of blood coagulation Source: BHF-UCL
Negative regulation of endothelial cell migration Source: BHF-UCL
Negative regulation of endothelial cell proliferation Source: BHF-UCL
Negative regulation of fibrinolysis Source: BHF-UCL
Negative regulation of myeloid cell apoptotic process Source: BHF-UCL
Negative regulation of smooth muscle cell apoptotic process Source: BHF-UCL
Plasminogen activation Source: BHF-UCL
Platelet degranulation Source: Reactome
Positive regulation of blood coagulation Source: BHF-UCL
Positive regulation of lipoprotein lipase activity Source: BHF-UCL
Regulation of fibrinolysis Source: BHF-UCL
Triglyceride metabolic process Source: BHF-UCL
Triglyceride transport Source: BHF-UCL
Cellular Location
Secreted
PTM
N- and O-glycosylated. PubMed:6587378 also reports glycosylation on 'Asn-188' for their allele.

Liu, Y., Maiers, J. L., Rui, Y., Jiang, X., Guleng, B., & Ren, J. (2021). Apolipoprotein H drives hepatitis B surface antigen retention and endoplasmic reticulum stress during hepatitis B virus infection. The International Journal of Biochemistry & Cell Biology, 131, 105906.

Liu, Y., Maiers, J. L., Wu, Y., Fu, B., Guo, X., Huang, X., ... & Ren, J. (2021). 713d Downregulation of Apolipoprotein H Induce Hepatocyte Steatosis to Promote Gut Microbiota Dysbiosis in Chronic Hepatitis B Infection. Gastroenterology, 161(2), e26.

Tan, Y., Bian, Y., Song, Y., Zhang, Q., & Wan, X. (2021). Exosome-Contained APOH Associated With Antiphospholipid Syndrome. Frontiers in Immunology, 12, 1237.

Wajda, A., Sowińska, A., Haładyj, E., Stypińska, B., Nałęcz-Janik, J., Jagodziński, P. P., ... & Paradowska-Gorycka, A. (2020). Tissue factor and human apolipoprotein H genetic variants and pro-inflammatory cytokines in systemic lupus erythematosus patients. Clinical and Experimental Rheumatology.

Khatri, S., Mellins, E. D., Torok, K. S., Bukhari, S. A., & Astakhova, K. (2020). Combined assay for detecting autoantibodies to nucleic acids and apolipoprotein H in patients with systemic lupus erythematosus. In Nucleic Acid Detection and Structural Investigations (pp. 57-71). Humana, New York, NY.

Abi Jomaa, R. (2020). Effects of Apolipoprotein H and STAT3 on Cell Clustering of Glioblastoma Multiforme Sub-Clones (Doctoral dissertation).

Zhang, X. P., Zeng, W., Liu, H., Tang, L., Wang, Q. Y., Cheng, Z. P., ... & Hu, Y. (2018). Thrombophilia Caused by Beta2-Glycoprotein I Deficiency: In Vitro Study of a Rare Mutation in APOH Gene. Current medical science, 38(2), 379-385.

e Cunha, C. S., Nyboer, B., Heiss, K., Sanches-Vaz, M., Fontinha, D., Wiedtke, E., ... & Mueller, A. K. (2017). Plasmodium berghei EXP-1 interacts with host Apolipoprotein H during Plasmodium liver-stage development. Proceedings of the National Academy of Sciences, 114(7), E1138-E1147.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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