Mouse Anti-APC Recombinant Antibody (CBYC-A661) (CBMAB-A3036-YC)

APC, WNT Signaling Pathway Regulator

APC is a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenoma

APC, WNT Signaling Pathway Regulator; Protein Phosphatase 1, Regulatory Subunit 46; Deleted In Polyposis 2.5; DP2.5; Adenomatosis Polyposis Coli Tumor Suppressor; Truncated Adenomatosis Polyposis Coli; Adenomatous Polyposis Coli Protein; WNT Signaling Pat

Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Beta-catenin destruction complex assembly Source: Reactome
Beta-catenin destruction complex disassembly Source: Reactome
Bicellular tight junction assembly Source: UniProtKB
Cell adhesion Source: UniProtKB
Cell cycle arrest Source: UniProtKB
Cell fate specification Source: GO_Central
Cell migration Source: UniProtKB
Cellular response to DNA damage stimulus Source: UniProtKB
Insulin receptor signaling pathway Source: CAFA
Mitotic cytokinesis Source: MGI
Mitotic spindle assembly checkpoint Source: MGI
Negative regulation of canonical Wnt signaling pathway Source: UniProtKB
Negative regulation of cell population proliferation Source: UniProtKB
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB
Negative regulation of G1/S transition of mitotic cell cycle Source: UniProtKB
Negative regulation of microtubule depolymerization Source: UniProtKB
Nervous system development Source: GO_Central
Pattern specification process Source: GO_Central
Positive regulation of apoptotic process Source: MGI
Positive regulation of cell death Source: CAFA
Positive regulation of cell migration Source: MGI
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Positive regulation of protein catabolic process Source: MGI
Positive regulation of protein localization to centrosome Source: CAFA
Positive regulation of pseudopodium assembly Source: MGI
Protein-containing complex assembly Source: UniProtKB
Protein deubiquitination Source: Reactome
Regulation of attachment of spindle microtubules to kinetochore Source: MGI
Regulation of cell differentiation Source: GO_Central
Regulation of microtubule-based process Source: UniProtKB
Wnt signaling pathway Source: Reactome

Cytoplasm; Ruffle membrane; Cell membrane; Cytoskeleton; Adherens junction; Lamellipodium. Associated with the microtubule network at the growing distal tip of microtubules (PubMed:19632184). Accumulates in the lamellipodium and ruffle membrane in response to hepatocyte growth factor (HGF) treatment (PubMed:19151759). The MEMO1-RHOA-DIAPH1 signaling pathway controls localization of the phosphorylated form to the cell membrane (PubMed:20937854).

Familial adenomatous polyposis 1 (FAP1): A cancer predisposition syndrome characterized by adenomatous polyps of the colon and rectum, but also of upper gastrointestinal tract (ampullary, duodenal and gastric adenomas). This is a viciously premalignant disease with one or more polyps progressing through dysplasia to malignancy in untreated gene carriers with a median age at diagnosis of 40 years.
Desmoid disease, hereditary (DESMD): An autosomal dominant disease characterized by multifocal fibromatosis of the abdominal wall and mesentery. Desmoid tumors can also affect paraspinal muscles, breast, occiput, arms, and lower ribs.
Medulloblastoma (MDB): Malignant, invasive embryonal tumor of the cerebellum with a preferential manifestation in children.
Gastric cancer (GASC): A malignant disease which starts in the stomach, can spread to the esophagus or the small intestine, and can extend through the stomach wall to nearby lymph nodes and organs. It also can metastasize to other parts of the body. The term gastric cancer or gastric carcinoma refers to adenocarcinoma of the stomach that accounts for most of all gastric malignant tumors. Two main histologic types are recognized, diffuse type and intestinal type carcinomas. Diffuse tumors are poorly differentiated infiltrating lesions, resulting in thickening of the stomach. In contrast, intestinal tumors are usually exophytic, often ulcerating, and associated with intestinal metaplasia of the stomach, most often observed in sporadic disease.
Hepatocellular carcinoma (HCC): A primary malignant neoplasm of epithelial liver cells. The major risk factors for HCC are chronic hepatitis B virus (HBV) infection, chronic hepatitis C virus (HCV) infection, prolonged dietary aflatoxin exposure, alcoholic cirrhosis, and cirrhosis due to other causes.

Phosphorylated by GSK3B.
Ubiquitinated, leading to its degradation by the proteasome. Ubiquitination is facilitated by Axin. Deubiquitinated by ZRANB1/TRABID.